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Effects of Vitamin C and E Combination on Element and Oxidative Stress Levels in the Blood of Operative Patients Under Desflurane Anesthesia

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Abstract

We investigated effects of vitamin C and E (VCE) administration on desflurane-induced oxidative toxicity and element changes in the blood of operative patients under desflurane general anesthesia. Forty American Society of Anesthesiologists I or II Physical Status adult patients were scheduled for elective surgery. The patients were randomly divided into two groups. Control and VCE group was introduced to anesthesia with desflurane. VCE was administreted to patients in the control and VCE group before 1 hour of anesthesia with desflurane. Baseline (preoperative) and postoperative (at the 1st, the 24th, and 72th h), blood samples were taken from the first and second groups. Erythrocyte and plasma lipid peroxidation levels at the 1st, 24th, and 72th hours were higher in the control than in baseline group, although their levels at the same periods were lower in the VCE group than in the control. Vitamin E levels at the postoperative 1st and 24th hours and erythrocyte glutathione peroxidase (GSH-Px) activity at the postoperative 1st, 24th, and 72th hours was lower than in baseline values. Erythrocyte GSH-Px activity and plasma vitamins A, C, and E levels at the postoperative 1st, 24th, and 72th hours were higher in the VCE group than in the control group. Erythrocyte and plasma reduced glutathione, plasma β-carotene, and serum copper, while zinc, selenium, aluminum, iron, magnesium, and calcium levels did not differ between preoperative and postoperative periods in both groups. In conclusion, VCE combination prevented the desflurane-induced vitamin E and GSH-Px consumptions to strengthen the antioxidant levels in the blood of operative patients.

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Abbreviations

CAT:

catalase

GSH:

reduced glutathione

GSH-Px:

glutathione peroxidase

Hb:

hemoglobin

I/R:

ischemia-reperfusion

LP:

lipid peroxidation

MDA:

malondialdehyde

ROS:

reactive oxygen species

SOD:

superoxide dismutase

VCE:

vitamin C and E

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Authors and Affiliations

  1. Department of Anesthesiology and Reanimation, Medical Faculty, Suleyman Demirel University, Isparta, Turkey

    Berit G. Ceylan, Bülent Erdem & Lütfi Yavuz

  2. Department of Biophysics, Medical Faculty, Süleyman Demirel University, Morfoloji Binasi, 32260, Isparta, Turkey

    Mustafa Nazıroğlu & A. Cihangir Uğuz

  3. Neuroscience Research Center, Suleyman Demirel University, Isparta, Turkey

    Mustafa Nazıroğlu

  4. Department of Chemistry, Science Institute, Balıkesir University, Balıkesir, Turkey

    Cihan Barak

Authors
  1. Berit G. Ceylan
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  2. Mustafa Nazıroğlu
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  3. A. Cihangir Uğuz
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  4. Cihan Barak
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  5. Bülent Erdem
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  6. Lütfi Yavuz
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Correspondence to Mustafa Nazıroğlu.

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Ceylan, B.G., Nazıroğlu, M., Uğuz, A.C. et al. Effects of Vitamin C and E Combination on Element and Oxidative Stress Levels in the Blood of Operative Patients Under Desflurane Anesthesia. Biol Trace Elem Res 141, 16–25 (2011). https://doi.org/10.1007/s12011-010-8712-3

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  • DOI: https://doi.org/10.1007/s12011-010-8712-3

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