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Effects of Multivitamin/Mineral Supplementation on Trace Element Levels in Serum and Follicular Fluid of Women Undergoing in Vitro Fertilization (IVF)

Biological Trace Element Research volume 139, pages 1–9 (2011)Cite this article

Abstract

We investigated effects of multivitamin/mineral supplementation on element levels in serum and follicular fluid of women undergoing IVF. We used three groups in this study. The first group was used as an age-matched and nonpregnant control (n = 13). Group 2 (n = 30) constituted the IVF group and women in the third group who were undergoing IVF also received a multivitamin/mineral tablet daily for 45 days. Follicular fluid and serum selenium and zinc levels and follicular fluid copper levels were lower in IVF patients than in controls although follicular fluid aluminum and iron levels were higher in IVF patients than in controls. However, follicular fluid and serum aluminum, copper, zinc and selenium levels, and serum magnesium levels were higher in the multivitamin/mineral group than in the IVF group although follicular fluid iron levels were lower in the multivitamin/mineral group than in the IVF group. In conclusion, we observed that copper, zinc, and selenium in serum and follicular fluid decreased in women undergoing IVF. Multivitamin/mineral supplementation in serum and follicular fluid of women undergoing IVF normalized the trace element levels.

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Abbreviations

FSH:

Follicle stimulating hormone

GSH-Px:

Glutathione peroxidase

hCG:

Human chorionic gonadotrophin

IVF:

In vitro fertilization

ROS:

Reactive oxygen species

SOD:

Superoxide dismutase

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Acknowledgment

The authors wish to thanks Prof. Dr. Hakan Kaya (IVF center, Isparta Private Hospital, Turkey) for helping samples collection and Dr. Peter Butterworth of King’s College, London for assistance with the presentation of the manuscript and correction of the English language.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey

    Mehmet Okan Özkaya

  2. Department of Biophysics, Medical Faculty, Suleyman Demirel University, Morfoloji Binasi, Cunur, 32260, Isparta, Turkey

    Mustafa Nazıroğlu

  3. Department of Chemistry, Science Institute, Balıkesir, Turkey

    Cihan Barak

  4. IVF Center of Antalya Private Hospital, Antalya, Turkey

    Murat Berkkanoglu

Authors
  1. Mehmet Okan Özkaya
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  2. Mustafa Nazıroğlu
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  3. Cihan Barak
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  4. Murat Berkkanoglu
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Correspondence to Mustafa Nazıroğlu.

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Özkaya, M.O., Nazıroğlu, M., Barak, C. et al. Effects of Multivitamin/Mineral Supplementation on Trace Element Levels in Serum and Follicular Fluid of Women Undergoing in Vitro Fertilization (IVF). Biol Trace Elem Res 139, 1–9 (2011). https://doi.org/10.1007/s12011-010-8637-x

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  • DOI: https://doi.org/10.1007/s12011-010-8637-x

Keywords

  • Zinc
  • Selenium
  • Copper
  • IVF
  • Human fertilization
  • Follicular fluid