Biological Trace Element Research

, Volume 136, Issue 3, pp 337–354 | Cite as

Prophylactic Efficacy of Coriandrum sativum (Coriander) on Testis of Lead-Exposed Mice

  • Veena SharmaEmail author
  • Leena Kansal
  • Arti Sharma


Lead poisoning is a worldwide health problem, and its treatment is under investigation. The aim of this study was to access the efficacy of Coriandrum sativum (coriander) in reducing lead-induced changes in mice testis. Animal exposed to lead nitrate showed significant decrease in testicular SOD, CAT, GSH, total protein, and tissue lead level. This was accompanied by simultaneous increase in the activities of LPO, AST, ALT, ACP, ALP, and cholesterol level. Serum testosterone level and sperm density were suppressed in lead-treated group compared with the control. These influences of lead were prevented by concurrent daily administration of C. sativum extracts to some extent. Treating albino mice with lead-induced various histological changes in the testis and treatment with coriander led to an improvement in the histological testis picture. The results thus led us to conclude that administration of C. sativum significantly protects against lead-induced oxidative stress. Further work need to be done to isolate and purify the active principle involved in the antioxidant activity of this plant.


Coriandrum sativum Testis Lead nitrate Histology Mice 



The authors are thankful to the authorities of Banasthali University for providing support to the study.

Conflict of Interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.


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© Humana Press Inc. 2009

Authors and Affiliations

  1. 1.Bioscience and Biotechnology DepartmentBanasthali UniversityBanasthaliIndia

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