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Effects of Artemisinin Derivative on the Growth Metabolism of Tetrahymena thermophila BF5 Based on Expression of Thermokinetics

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Abstract

The toxic effects of artesunate and dihydroartemisinin on the growth metabolism of Tetrahymena thermophila BF5 were studied by microcalorimetry. The results showed that: (1) low concentrations of artesunate (≤1 mg L−1) and dihydroartemisinin (≤ 2 mg L−1) promoted the growth metabolism of T. thermophila BF5, whereas high concentrations of artesunate (1–60 mg L−1) and dihydroartemisinin (2–60 mg L−1) inhibited its growth; (2) the half inhibition concentrations IC50 of artesunate and dihydroartemisinin were 17.5817 and 9.5089 mg L−1, respectively. It was concluded that the inhibition of dihydroartemisinin was stronger than that of artesunate.

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Acknowledgment

This work was financially supported by the Natural Science Foundation of Guangxi (no. 0728227).

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Authors and Affiliations

  1. College of Pharmacy, Guilin Medical University, Guilin, Guangxi, 541004, People’s Republic of China

    Xue-Song Shen, Qi Su, Zhuang-ping Qiu, Jing-yi Xu, Yan-xia Xie, Han-fu Liu & Yi Liu

  2. Chemistry and Molecule Scientific Institute, Wuhan University, Wuhan, Hubei, 430072, People’s Republic of China

    Yi Liu

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  1. Xue-Song Shen
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  2. Qi Su
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Correspondence to Xue-Song Shen.

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Shen, XS., Su, Q., Qiu, Zp. et al. Effects of Artemisinin Derivative on the Growth Metabolism of Tetrahymena thermophila BF5 Based on Expression of Thermokinetics. Biol Trace Elem Res 136, 117–125 (2010). https://doi.org/10.1007/s12011-009-8527-2

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  • DOI: https://doi.org/10.1007/s12011-009-8527-2

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