Abstract
This study aims at determining possible association between serum magnesium (Mg) concentrations and metabolic syndrome (MetS) in elderly subjects. Subjects were 137 men and women aged 60 to 90 years, selected from among participants of the Tehran Lipid and Glucose Study after excluding those taking medications for hypertension and dyslipidemia. Serum Mg levels were measured by atomic absorption spectrometry and MetS was defined according to ATP III criteria. The overall prevalence of MetS was 43.8%. Among MetS components, only plasma glucose showed a negative correlation with serum Mg concentrations (r = −0.194, p = 0.024). Subjects with MetS had significantly lower serum Mg concentrations compared with non-MetS ones (2.09 ± 0.03 vs. 2.18 ± 0.03 mg/dL, p = 0.033) even after adjustments with MetS components except for hyperglycemia (2.04 ± 0.06 vs. 2.20 ± 0.05 mg/dL, p = 0.011). However, after adjustment for hyperglycemia per se or along with the other MetS components, the significant difference between serum Mg levels in subjects with and without MetS disappeared. In conclusion, serum Mg level is diminished in elderly subjects with MetS, and hyperglycemia may play dominant role in this decrease; however, the results do not clarify whether the low serum Mg level is a consequence of hyperglycemia or is a risk factor contributing to its development.
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Meigs JB (2000) Invited commentary: insulin resistance syndrome? Syndrome X? Multiple metabolic syndrome? A syndrome at all? Factor analysis reveals patterns in the fabric of correlated metabolic risk factors. Am J Epidemiol 152:908–911, discussion 912
Pladevall M, Singal B, Williams LK, Brotons C, Guyer H, Sadurni J, Falces C, Serrano-Rios M, Gabriel R, Shaw JE, Zimmet PZ, Haffner S (2006) A single factor underlies the metabolic syndrome: a confirmatory factor analysis. Diabetes Care 29:113–122
Denys K, Cankurtaran M, Janssens W, Petrovic M (2009) Metabolic syndrome in the elderly: an overview of the evidence. Acta Clin Belg 64:23–34
Hadaegh F, Zabetian A, Tohidi M, Ghasemi A, Sheikholeslami F, Azizi F (2009) Prevalence of metabolic syndrome by the Adult Treatment Panel III, International Diabetes Federation, and World Health Organization definitions and their association with coronary heart disease in an elderly Iranian population. Ann Acad Med Singapore 38:142–149
Anderson PJ, Critchley JA, Chan JC, Cockram CS, Lee ZS, Thomas GN, Tomlinson B (2001) Factor analysis of the metabolic syndrome: obesity vs insulin resistance as the central abnormality. Int J Obes Relat Metab Disord 25:1782–1788
Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa L, Pineo A, Busardo A, Paolisso G (2003) Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Mol Aspects Med 24:39–52
Chaudhary DP, Sharma R, Bansal DD (2009) Implications of magnesium deficiency in type 2 diabetes: a review. Biol Trace Elem Res [in press]
Elin RJ (1987) Assessment of magnesium status. Clin Chem 33:1965–1970
Kao WH, Folsom AR, Nieto FJ, Mo JP, Watson RL, Brancati FL (1999) Serum and dietary magnesium and the risk for type 2 diabetes mellitus: the atherosclerosis risk in communities study. Arch Intern Med 159:2151–2159
Takaya J, Higashino H, Kobayashi Y (2004) Intracellular magnesium and insulin resistance. Magnes Res 17:126–136
Schimatschek HF, Rempis R (2001) Prevalence of hypomagnesemia in an unselected German population of 16,000 individuals. Magnes Res 14:283–290
Davidovic M, Trailov D, Milosevic D, Radosavljevic B, Milanovic P, Djurica S, Loncar-Stevanovic H, Stevic R (2004) Magnesium, aging, and the elderly patient. Scientific World Journal 4:544–550
He K, Liu K, Daviglus ML, Morris SJ, Loria CM, Van Horn L, Jacobs DR Jr, Savage PJ (2006) Magnesium intake and incidence of metabolic syndrome among young adults. Circulation 113:1675–1682
Lopez-Ridaura R, Willett WC, Rimm EB, Liu S, Stampfer MJ, Manson JE, Hu FB (2004) Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care 27:134–140
Chambers EC, Heshka S, Gallagher D, Wang J, Pi-Sunyer FX, Pierson RN Jr (2006) Serum magnesium and type-2 diabetes in African Americans and Hispanics: a New York cohort. J Am Coll Nutr 25:509–513
Guerrero-Romero F, Rodriguez-Moran M (2002) Low serum magnesium levels and metabolic syndrome. Acta Diabetol 39:209–213
Lima Mde L, Cruz T, Rodrigues LE, Bomfim O, Melo J, Correia R, Porto M, Cedro A, Vicente E (2009) Serum and intracellular magnesium deficiency in patients with metabolic syndrome—evidences for its relation to insulin resistance. Diabetes Res Clin Pract 83:257–262
Evangelopoulos AA, Vallianou NG, Panagiotakos DB, Georgiou A, Zacharias GA, Alevra AN, Zalokosta GJ, Vogiatzakis ED, Avgerinos PC (2008) An inverse relationship between cumulating components of the metabolic syndrome and serum magnesium levels. Nutr Res 28:659–663
Azizi F, Rahmani M, Emami H, Mirmiran P, Hajipour R, Madjid M, Ghanbili J, Ghanbarian A, Mehrabi Y, Saadat N, Salehi P, Mortazavi N, Heydarian P, Sarbazi N, Allahverdian S, Saadati N, Ainy E, Moeini S (2002) Cardiovascular risk factors in an Iranian urban population: Tehran lipid and glucose study (phase 1). Soz Praventivmed 47:408–426
Hunt BJ (1969) The estimation of magnesium in plasma, muscle and bone, by atomic absorption spectrophotometry. Clin Chem 15:979–996
Panel E (2001) Executive summary of The Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285:2486–2497
Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20:1183–1197
Ravaglia G, Forti P, Maioli F, Bastagli L, Chiappelli M, Montesi F, Bolondi L, Patterson C (2006) Metabolic syndrome: prevalence and prediction of mortality in elderly individuals. Diabetes Care 29:2471–2476
Gause-Nilsson I, Gherman S, Kumar Dey D, Kennerfalk A, Steen B (2006) Prevalence of metabolic syndrome in an elderly Swedish population. Acta Diabetol 43:120–126
Resnick LM (1993) Ionic basis of hypertension, insulin resistance, vascular disease, and related disorders. The mechanism of “syndrome X”. Am J Hypertens 6:123S–134S
Barbagallo M, Resnick LM (1994) The role of glucose in diabetic hypertension: effects on intracellular cation metabolism. Am J Med Sci 307(Suppl 1):S60–S65
Saha H, Harmoinen A, Karvonen AL, Mustonen J, Pasternack A (1998) Serum ionized versus total magnesium in patients with intestinal or liver disease. Clin Chem Lab Med 36:715–718
Acknowledgements
This work was supported by a grant (No. 221) from the Research Institute for Endocrine Sciences of Shahid Beheshti University of Medical Sciences. We are indebted to the residents of District 13, Tehran, who participated in the study. We thank Ms. L. Saidmoradi for the technical assistance with the study and Ms. N. Shiva for the critical editing of English grammar and syntax of the manuscript.
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Ghasemi, A., Zahediasl, S., Syedmoradi, L. et al. Low Serum Magnesium Levels in Elderly Subjects with Metabolic Syndrome. Biol Trace Elem Res 136, 18–25 (2010). https://doi.org/10.1007/s12011-009-8522-7
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DOI: https://doi.org/10.1007/s12011-009-8522-7