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Effects of Cadmium on Absorption, Excretion, and Distribution of Nickel in Rats

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Abstract

The effects of cadmium (Cd (II)) on absorption, excretion, and distribution of nickel (Ni (II)) were studied in rats using 63Ni-NiCl2 as radiotracer in the presence and absence of CdCl2, through intraperitoneal injection (i.p.). The time–concentration curves in the blood were fitted with a two-compartment model. The peak time (t (peak)) is 0.31 h in the absence of Cd (II), and it is 5.5 h in the presence of Cd (II). The levels of nickels were higher at 3 h and lower (close to zero) at 24 h in all organs of interest, except kidneys, in the absence of Cd (II). There still residue Ni (II) at 72 h post-injection in the presence of Cd (II). The Cd (II) did effect the total Ni (II) excretion 24 h post-injection. Our study showed that cadmium has a competitive effect on the absorption of nickel and an inhibitory effect on the elimination of it, so cadmium may induce the bioaccumulation of nickel in the body.

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Acknowledgments

This study was conducted with financial support from National Natural Science Foundation of China (20871062, J0630962). Dr. Youwen Xu from BNK is thanked for her revision.

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Authors and Affiliations

  1. Radiochemistry Laboratory, Lanzhou University, Lanzhou, 73000, People’s Republic of China

    Zhan Li, Qiao-Hui Fan, Yan-Xia Geng & Wang-Suo Wu

  2. Departments of Neuroscience and Anatomy, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 73000, People’s Republic of China

    Jun-Ying Gu, Xian-Wen Wang & Yi-Ping Hou

  3. Department of Pathology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 73000, People’s Republic of China

    Zong-Xian Jiao

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  1. Zhan Li
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  2. Jun-Ying Gu
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  5. Yan-Xia Geng
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  8. Wang-Suo Wu
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Correspondence to Wang-Suo Wu.

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Li, Z., Gu, JY., Wang, XW. et al. Effects of Cadmium on Absorption, Excretion, and Distribution of Nickel in Rats. Biol Trace Elem Res 135, 211–219 (2010). https://doi.org/10.1007/s12011-009-8483-x

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  • DOI: https://doi.org/10.1007/s12011-009-8483-x

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