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Implications of Magnesium Deficiency in Type 2 Diabetes: A Review

Biological Trace Element Research volume 134, pages 119–129 (2010)Cite this article

Abstract

Magnesium is the fourth most abundant cation in the body and plays an important physiological role in many of its functions. It plays a fundamental role as a cofactor in various enzymatic reactions involving energy metabolism. Magnesium is a cofactor of various enzymes in carbohydrate oxidation and plays an important role in glucose transporting mechanism of the cell membrane. It is also involved in insulin secretion, binding, and activity. Magnesium deficiency and hypomagnesemia can result from a wide variety of causes, including deficient magnesium intake, gastrointestinal, and renal losses. Chronic magnesium deficiency has been associated with the development of insulin resistance. The present review discusses the implications of magnesium deficiency in type 2 diabetes.

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Authors and Affiliations

  1. Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana, 141004, India

    Dharam P. Chaudhary

  2. Department of Biochemistry, Panjab University, Chandigarh, 160014, India

    Rajeshwar Sharma & Devi D. Bansal

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  1. Dharam P. Chaudhary
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  3. Devi D. Bansal
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Correspondence to Dharam P. Chaudhary.

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Chaudhary, D.P., Sharma, R. & Bansal, D.D. Implications of Magnesium Deficiency in Type 2 Diabetes: A Review. Biol Trace Elem Res 134, 119–129 (2010). https://doi.org/10.1007/s12011-009-8465-z

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Keywords

  • Magnesium
  • Insulin resistance
  • Diabetes
  • Cardiovascular diseases