Biological Trace Element Research

, Volume 134, Issue 2, pp 119–129 | Cite as

Implications of Magnesium Deficiency in Type 2 Diabetes: A Review

  • Dharam P. ChaudharyEmail author
  • Rajeshwar Sharma
  • Devi D. Bansal


Magnesium is the fourth most abundant cation in the body and plays an important physiological role in many of its functions. It plays a fundamental role as a cofactor in various enzymatic reactions involving energy metabolism. Magnesium is a cofactor of various enzymes in carbohydrate oxidation and plays an important role in glucose transporting mechanism of the cell membrane. It is also involved in insulin secretion, binding, and activity. Magnesium deficiency and hypomagnesemia can result from a wide variety of causes, including deficient magnesium intake, gastrointestinal, and renal losses. Chronic magnesium deficiency has been associated with the development of insulin resistance. The present review discusses the implications of magnesium deficiency in type 2 diabetes.


Magnesium Insulin resistance Diabetes Cardiovascular diseases 


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Copyright information

© Humana Press Inc. 2009

Authors and Affiliations

  • Dharam P. Chaudhary
    • 1
    Email author
  • Rajeshwar Sharma
    • 2
  • Devi D. Bansal
    • 2
  1. 1.Department of Plant Breeding and GeneticsPunjab Agricultural UniversityLudhianaIndia
  2. 2.Department of BiochemistryPanjab UniversityChandigarhIndia

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