Short-Term Oral Magnesium Supplementation Suppresses Bone Turnover in Postmenopausal Osteoporotic Women

Biological Trace Element Research volume 133, pages136–143(2010)Cite this article

Abstract

Magnesium has been shown to increase bone mineral density when used in the treatment of osteoporosis, yet its mechanism of action is obscure. In this study, the effects of daily oral magnesium supplementation on biochemical markers of bone turnover were investigated. Twenty postmenopausal women have been divided into two groups. Ten patients were given magnesium citrate (1,830 mg/day) orally for 30 days. Ten postmenopausal women of matching age, menopause duration, and BMI were recruited as the control group and followed without any medication. Fasting blood and first-void urine samples were collected on days 0, 1, 5, 10, 20, and 30, respectively. Total magnesium, calcium, phosphorus, iPTH and osteocalcin were determined in blood samples. Deoxypyridinoline levels adjusted for creatinine were measured in urine samples. Thirty consecutive days of oral magnesium supplementation caused significantly decrease in serum iPTH levels in the Mg-supplemented group (p < 0.05). Serum osteocalcin levels were significantly increased (p < 0.001) and urinary deoxypyridinoline levels were decreased (p < 0.001) in the Mg-supplemented group. This study has demonstrated that oral magnesium supplementation in postmenopausal osteoporotic women suppresses bone turnover.

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References

  1. 1.

    Tranquilli AL, Lucino E, Garzetti GG, Romanini C (1994) Calcium, phosphorus and magnesium intakes correlate with bone mineral content in postmenopausal women. Gynecol Endocrinol 1:55–58

    Article  Google Scholar 

  2. 2.

    Reginster JY, Strause L, Deroisy R, Lecart MP, Saltman P, Franchimont P (1989) Preliminary report of decreased serum magnesium in postmenopausal osteoporosis. Magnesium 8(2):106–109

    CAS  PubMed  Google Scholar 

  3. 3.

    Steidl L, Ditmar R (1991) Blood magnesium, calcium and zinc in osteoporosis. Acta Univ Palacki Olomuc Fac Med 129:91–98

    CAS  PubMed  Google Scholar 

  4. 4.

    Ditmar R, Steidl L (1989) The significance of magnesium in orthopedics. Magnesium in osteoporosis. Acta Chir Orthop Traumatol Cech 56(2):143–159

    CAS  PubMed  Google Scholar 

  5. 5.

    Cohen L (1988) Recent data on magnesium and osteoporosis. Magnes Res 1–2:85–87

    Google Scholar 

  6. 6.

    Wallach S (1990) Effects of magnesium on skeletal metabolism. Magnes Trace Elem 9(1):1–14

    CAS  PubMed  Google Scholar 

  7. 7.

    Yano K, Heilbrun LK, Wasnich RD, Hankin JH, Vogel JM (1985) The relationship between diet and bone mineral content of multiple skeletal sites in elderly Japanese–American men and women living in Hawaii. Am J Clin Nutr 42:877–888

    CAS  PubMed  Google Scholar 

  8. 8.

    Schaafsma A, Pakan I (1999) Short-term effects of a chicken egg shell powder enriched dairy-based product on bone mineral density in persons with osteoporosis or osteopenia. Bratisl Lek Listy 12:651–656

    Google Scholar 

  9. 9.

    Sojka JE, Weaver JM (1995) Magnesium supplementation and osteoporosis. Nutr Rev 53(3):71–74

    CAS  PubMed  Google Scholar 

  10. 10.

    Eisinger J, Clairet D (1993) Effects of silicone, fluoride, etidronate and magnesium on bone mineral density: a retrospective study. Magnes Res 3:247–249

    Google Scholar 

  11. 11.

    Dimai HP, Porta S, Wirnsberger G, Lindschinger M, Pamperl I, Dobnig H, Wilders-Truschnig M, Lau KH (1998) Daily oral magnesium supplementation suppresses bone turnover in young adult males. J Clin Endocrinol Metab 83(8):2742–2748

    Article  CAS  PubMed  Google Scholar 

  12. 12.

    Doyle L, Flynn A, Cashman K (1999) The effect of magnesium supplementation on biochemical markers of bone metabolism or blood pressure in healthy young adult females. Eur J Clin Nutr 53(4):255–261

    Article  CAS  PubMed  Google Scholar 

  13. 13.

    Toba Y, Kajita Y, Masuyama R, Takada Y, Suzuki K, Aoe S (2000) Dietary magnesium supplementation affects bone metabolism and dynamic strength of bone in ovariectomized rats. J Nutr 130(2):216–220

    CAS  PubMed  Google Scholar 

  14. 14.

    WHO (1994) Assessment of osteoporotic fracture risk and its role in screening for postmenopausal osteoporosis. WHO Technical Report Series, Genova

    Google Scholar 

  15. 15.

    Kress BC, Mizrahi IA (1999) Monitoring antiosteoporotic treatment of postmenopausal women using biochemical markers of bone turnover. Drugs Today (Barc) 35(3):181–185

    CAS  Google Scholar 

  16. 16.

    Delmas PD (1993) Biochemical markers of bone turnover. J Bone Miner Res 8(suppl2):S549–555

    PubMed  Article  Google Scholar 

  17. 17.

    Chapurlat RD, Garnero P, Breart G, Meunier PJ, Delmas PD (2000) Serum estradiol and sex hormone binding globulin and the risk of hip fracture. J Bone Miner Res 15(9):1835–1841

    Article  CAS  PubMed  Google Scholar 

  18. 18.

    Eyre DR (1997) Bone biomarkers as a tool in osteoporosis management. Spine 24(Suppl):S17–S24

    Article  Google Scholar 

  19. 19.

    Overgaard K, Hansen MA, Jensen SB, Christiansen C (1992) Effect of salcatonin given intra-nasally on bone mass and fracture rates in established osteoporosis: a dose-response study. Br Med J 305:556–561

    Article  CAS  Google Scholar 

  20. 20.

    Harris ST, Gertz BJ, Genant HK, Eyre DR, Survill TT, Ventura JN, De Brock J, Ricerco E, Chesnut CH 3rd (1993) The effect of short term treatment with alendronate on vertebral density and biochemical markers of bone remodeling in early postmenopausal women. J Clin Endocrinol Metab 76(6):1399–1406

    Article  CAS  PubMed  Google Scholar 

  21. 21.

    Epstein S, Poser J, McClintock R, Johnston CC Jr, Bryce G, Hui S (1984) Differences in bone GLA protein with age and sex. Lancet 8372:307–310

    Article  Google Scholar 

  22. 22.

    Chesnut CH 3rd, Harris ST (1993) Short term effect of alendronate on bone mass and bone remodeling in postmenopausal women. Osteopros Int 3(Suppl 3):S17–S19

    Article  Google Scholar 

  23. 23.

    Clifford JR, Charles H, Chesnut CH 3rd, Nancy JSM (1997) The predictive value of biochemical markers of bone turnover for bone mineral density in early postmenopausal women treated with hormone replacement or calcium supplementation. J Clin Endocrinol Metab 82(6):1904–1910

    Article  Google Scholar 

  24. 24.

    Rude RK, Gruber HE (2004) Magnesium deficiency and osteoporosis: animal and human observations. J Nutr Biochem 15:710–716

    Article  CAS  PubMed  Google Scholar 

  25. 25.

    Rude RK, Gruber HE, We LY, Frausto A, Mills BG (2003) Magnesium deficiency: effect on bone and mineral metabolism in the mouse. Calcif Tissue Int 72:32–41

    Article  CAS  PubMed  Google Scholar 

  26. 26.

    Creedon A, Flynn A, Cashman K (1999) The effect of moderately and severely restricted dietary magnesium intakes on bone composition and bone metabolism in the rat. Br J Nutr 82:63–71

    CAS  PubMed  Google Scholar 

  27. 27.

    Arnaud CD, Sanchez SD (1990) The role of calcium in osteoporosis. Annu Rev Nutr 10:397–414

    Article  CAS  PubMed  Google Scholar 

  28. 28.

    Rude RK, Oldham SB, Sharp CF Jr, Singer FR (1978) Parathyroid hormone secretion in magnesium deficiency. J Clin Endocrinol Metab 47:800–806

    Article  CAS  PubMed  Google Scholar 

  29. 29.

    Marie PJ, Travers R, Delvin EF (1983) Influence of magnesium supplementation on bone turnover in the normal young mouse. Calcif Tissue Int 35(6):755–761

    Article  CAS  PubMed  Google Scholar 

  30. 30.

    Carpenter TO, Mackowiak SJ, Troiano N, Gundberg CM (1992) Osteocalcin and its message: relationship to bone histology in Mg-deprived rats. Am J Physiol 26:E106–E114

    Google Scholar 

  31. 31.

    Rude RK, Gruber HE, Norton HJ, Wei LY, Frausto A, Mills BG (2004) Bone loss induced by dietary magnesium reduction to 10% of the nutrient requirement in rats is associated with increased release of substance P and tumor necrosis factor-alpha. J Nutr 134(1):79–85

    CAS  PubMed  Google Scholar 

  32. 32.

    Makgoba MW, Datta HK (1992) The critical role of magnesium ions in osteoclast-matrix interaction: implications for divalent cations in the study of osteoclastic adhesion molecules and bone resorption. Eur J Clin Invest 22(10):692–696

    Article  CAS  PubMed  Google Scholar 

  33. 33.

    Weglicki WB, Phillips TM, Freedman AM, Cassidy MM, Dickens BF (1992) Magnesium deficiency elevates circulating levels of inflammatory cytokines and endothelin. Mol Cell Biochem 110(2):169–173

    Article  CAS  PubMed  Google Scholar 

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Affiliations

  1. Department of Internal Medicine, Section of Endocrinology and Metabolism, Yeditepe University Hospital, Devlet Yolu Ankara Cad. No: 102, Kozyatagi, Istanbul, 34752, Turkey

    Hasan Aydın

  2. Department of Internal Medicine, Section of Endocrinology and Metabolism, Marmara University Medical Faculty, Istanbul, Turkey

    Oğuzhan Deyneli, Dilek Yavuz, Işık Kaygusuz & Sema Akalın

  3. Department of Endocrinology and Metabolism, Kartal Lutfu Kirdar Education and Research Hospital, Istanbul, Turkey

    Hülya Gözü

  4. Department of Biochemistry, Yeditepe University Hospital, Istanbul, Turkey

    Nilgün Mutlu

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  1. Hasan Aydın
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  2. Oğuzhan Deyneli
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  4. Hülya Gözü
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  5. Nilgün Mutlu
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Correspondence to Hasan Aydın.

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Aydın, H., Deyneli, O., Yavuz, D. et al. Short-Term Oral Magnesium Supplementation Suppresses Bone Turnover in Postmenopausal Osteoporotic Women. Biol Trace Elem Res 133, 136–143 (2010). https://doi.org/10.1007/s12011-009-8416-8

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Keywords

  • Postmenopausal osteoporosis
  • Magnesium
  • Bone turnover