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Selenium-dependent Glutathione Peroxidase Activity is Increased in Healthy Post-menopausal Women

Biological Trace Element Research volume 131, pages 90–95 (2009)Cite this article

Abstract

Selenium helps protect against peroxidation during aging as part of the glutathione peroxidase (GPx) antioxidant system. Selenium status, however, is often low in elderly persons who have low selenium intake, live in institutions, and have certain chronic diseases. In addition, a relationship has been observed between the female reproductive hormone, estrogen, and selenium status, with blood selenium and GPx activity coinciding with fluctuations in estrogen during the menstrual cycle. These findings suggest that the decrease in estrogen following menopause may cause a decrease in selenium status, and thus accelerate the process of aging and increase the risk of certain diseases. The current study compared selenium status in healthy premenopausal (n = 13, 21 to 43 years) and postmenopausal (n = 10, 57 to 86 years) women. Selenium intakes of both groups were similar and greater than the recommended dietary allowance (RDA) of 55 µg/day for adult women. Although neither plasma nor RBC selenium concentrations were significantly different between groups, postmenopausal women had significantly greater plasma (p < 0.02), and RBC (p < 0.05) GPx activities compared to premenopausal women possibly in response to oxidative processes associated with aging. These results indicate that the selenium status of healthy postmenopausal women did not decline with menopause and that their antioxidant capability, as measured by GPx activity, was preserved with dietary intake of selenium greater than the RDA.

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  1. Eun-Jeong Ha

    Present address: Family and Consumer Studies, Kent State University, 130 Nixson Hall, Kent, OH, 44242, USA

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  1. Department of Human Nutrition, The Ohio State University, Columbus, OH, 43210, USA

    Eun-Jeong Ha & Anne M. Smith

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  1. Eun-Jeong Ha
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Correspondence to Eun-Jeong Ha.

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Ha, EJ., Smith, A.M. Selenium-dependent Glutathione Peroxidase Activity is Increased in Healthy Post-menopausal Women. Biol Trace Elem Res 131, 90–95 (2009). https://doi.org/10.1007/s12011-009-8346-5

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  • DOI: https://doi.org/10.1007/s12011-009-8346-5

Keywords

  • Selenium
  • Glutathione peroxidase
  • Menopause