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Magnesium Sulfate in Emergency Department Patients with Hypertension

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Abstract

To compare the effect of IV magnesium with other antihypertensives in emergency department (ED) patients with hypertension. ED patients with a systolic BP > 135 mmHg or diastolic BP > 85 were approached for entry into the study. Those granting consent were randomly placed into one of three treatment groups: (1) 1.5 gm IV MgSO4 (n = 42), (2) a parenteral or oral antihypertensive agent (n = 41), (3) both IV MgSO4 and an antihypertensive agent (n = 44). Systolic and diastolic blood pressures were measured at entry into the study and at 15, 30, 45, and 60 min after magnesium or other antihypertensive medications were given. The main outcome measure was blood pressure at 60 min, and results were compared using one-way analysis of variance with the post hoc Tukey HSD test. Compared to systolic and diastolic blood pressures at time 0, both were lower at 15, 30, 45, and 60 min in all groups (p < 0.05). No significant difference in systolic or diastolic BP at any time point was observed when response to treatment was compared between the three groups. Intravenous MgSO4 is as effective as antihypertensives at lowering BP in emergency department patients.

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Authors and Affiliations

  1. Department of Emergency Medicine, Meram Faculty of Medicine, Selçuk University, Meram, Konya, 42080, Turkey

    Ayşegül Bayır, Hasan Kara, Ahmet Ak & Başar Cander

  2. Department of Community Health, Selçuk University, Meram, Konya, 42080, Turkey

    Fatih Kara

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  1. Ayşegül Bayır
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  2. Hasan Kara
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  3. Ahmet Ak
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  4. Başar Cander
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  5. Fatih Kara
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Correspondence to Ayşegül Bayır.

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Bayır, A., Kara, H., Ak, A. et al. Magnesium Sulfate in Emergency Department Patients with Hypertension. Biol Trace Elem Res 128, 38–44 (2009). https://doi.org/10.1007/s12011-008-8256-y

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  • DOI: https://doi.org/10.1007/s12011-008-8256-y

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