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Serum Total Selenium Status in Greek Adults and Its Relation to Age. The ATTICA Study Cohort

Biological Trace Element Research volume 128, Article number: 8 (2009) Cite this article

Abstract

The trace element selenium is an essential micronutrient for human health and its low levels in serum are implicated in the pathogenesis of several chronic diseases. Therefore, the determination of total selenium in serum may contribute to the assessment of the health and nutritional status of certain populations. The objective of the present work was to determine total selenium in the serum of 506 healthy volunteers that participated in the ATTICA study. Selenium was determined in serum by using the technique of inductively coupled plasma mass spectrometry. The mean serum selenium concentration was determined to be 91.8 ± 33.7 μg/L (N = 506); 87.6% of women and 88.5% of men had serum selenium concentration below 125 μg/L, the cutoff considered to be required for optimal glutathione peroxidase activity. No association was found between serum selenium levels and the gender of the participants while a significant decline of selenium with age (p < 0.0001) was observed. According to our results, no anthropometric, lifestyle, nutritional, or biochemical indices were able to affect the association between serum selenium and age. This result may indicate that other factors such as selenium distribution as well as retention may be affecting the relationship between serum selenium and age.

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References

  1. Rayman MP (2000) The importance of selenium to human health. Lancet 356:233–241

    PubMed  Article  CAS  Google Scholar 

  2. Navarro-Alarcon M, Lopez-Martinez MC (2000) Essentiality of selenium in the human body: relationship with different diseases. Sci Total Environ 249:347–371

    PubMed  Article  CAS  Google Scholar 

  3. Clark R, Strukle E, Williams S, Manoguerra A (1996) Selenium poisoning from a nutritional supplement. J Am Med Assoc 275:1087–1088

    Article  CAS  Google Scholar 

  4. Schrauzer GN (2000) Anticarcinogenic effects of selenium. Cell Mol Life Sci 57:1864–1873

    PubMed  Article  CAS  Google Scholar 

  5. Brown KM, Arthur JR (2001) Selenium, selenoproteins and human health: a review. Public Health Nutr 4:593–599

    PubMed  Article  CAS  Google Scholar 

  6. Papp LV, Lu J, Holmgren A, Khanna KK (2007) From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal 7:775–806

    Google Scholar 

  7. Van Cauwenbergh R, Robberecht H, Deelstra H, Picramenos D, Kostakopoulos A (1994) Selenium concentration in serum of healthy Greek adults. J. Trace Elem Electrolytes Health Dis 8:99–109

    PubMed  Google Scholar 

  8. Schrauzer GN, White DA, Schneider CJ (1977) Cancer mortality correlation studies—III: statistical associations with dietary selenium intakes. Bioinorg Chem 71:23–31

    Article  Google Scholar 

  9. Schulpis KA, Karakonstantakis T, Gavrili S, Chronopoulou G, Karikas GA, Vlachos G, Papassotiriou I (2004) Maternal—neonatal serum selenium and copper levels in Greeks and Albanians. Eur J Clin Nutr 58:1314–1318

    PubMed  Article  CAS  Google Scholar 

  10. Pitsavos C, Panagiotakos DB, Chrysohoou C, Stefanadis C (2003) Epidemiology of cardiovascular risk factors in Greece: aims, design and baseline characteristics of the ATTICA study. BMC Public Health 3:32–41

    PubMed  Article  Google Scholar 

  11. Katsouyanni K, Rimm EB, Gnardellis C, Trichopoulos D, Polychronopoulos E, Trichopoulou A (1997) Reproducibility and relative validity of an extensive semi-quantitative food frequency questionnaire using dietary records and biochemical markers among Greek schoolteachers. Int J Epidemiol 26:118–127

    Article  Google Scholar 

  12. Hallal PC, Victora CG (2004) Reliability and validity of the International Physical Activity Questionnaire (IPAQ). Med Sci Sports Exerc 35:1381–1395

    Google Scholar 

  13. Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of dye-binding. Anal Biochem 72:248–254

    PubMed  Article  CAS  Google Scholar 

  14. Delves T, Sieniawska C (1997) Simple method for accurate determination of selenium in serum by using Inductively Coupled Plasma Mass Spectrometry. JAAS 12:387–389

    CAS  Google Scholar 

  15. Kallistros G, Evangelou A, Seferiadis K, Vezyraki P, Barboutis K (1985) Selenium and haemodialysis: serum selenium levels in healthy persons, non-cancer and cancer patients with chronic renal failure. Nephron 41:217–222

    Article  Google Scholar 

  16. Kostakopoulos A, Kotsalos A, Alexopoulos J, Sofras F, Deliveliotis C, Kallistratos G (1990) Serum selenium levels in healthy adults and its changes in chronic renal failure. Int Urol Nephrol 22:397–401

    PubMed  Article  CAS  Google Scholar 

  17. Milias G, Nomikos G, Fragopoulou E, Athanasopoulos S, Antonopoulou S (2006) Effects of baseline serum levels of Se on markers of eccentric exercise-induced muscle injury. Biofactors 26:161–170

    PubMed  Article  CAS  Google Scholar 

  18. Thomson CD (2004) Assessment of requirements for selenium and adequacy of selenium status: a review. Eur J Clin Nutr 58:391–402

    PubMed  Article  CAS  Google Scholar 

  19. Li N, Gao Z, Luo D, Tang X, Chen D, Hu Y (2007) Selenium level in the environment and the population of Zhoukoudian area, Beijing, China. Sci Total Environ 381:105–111

    PubMed  Article  CAS  Google Scholar 

  20. Chen CJ, Lai JS, Wu CC, Lin TS (2006) Serum selenium in adult Taiwanese. Sci Total Environ 367:448–450

    PubMed  Article  CAS  Google Scholar 

  21. Ghayour-Mobarhan M, Taylor A, New SA, Lamb DJ, Ferns GA (2005) Determinants of serum copper, zinc and selenium in healthy subjects. Ann Clin Biochem 42:364–375

    PubMed  Article  CAS  Google Scholar 

  22. Lopes PA, Santos MC, Vicente L, Rodrigues MO, Pavão ML, Nève J, Viegas-Crespo AM (2004) Trace element status (Se, Cu, Zn) in healthy Portuguese subjects of Lisbon population: a reference study. Biol Trace Elem Res 101:1–17

    PubMed  Article  CAS  Google Scholar 

  23. Brtková A, Magálová T, Babinská K, Béderová A (1994) Serum selenium levels in Slovak population. Biol Trace Elem Res 46:163–171

    PubMed  Article  Google Scholar 

  24. Korunová V, Skodová Z, Dĕdina J, Valenta J, Parizek J, Písa Z, Stýblo M (1993) Serum selenium in adult Czechoslovak (central Bohemia) population. Biol Trace Elem Res 37:91–99

    PubMed  Article  Google Scholar 

  25. Luty-Frackiewicz A, Jethon Z, Januszewska L (2002) Effect of smoking and alcohol consumption on the serum selenium level of Lower Silesian population. Sci Total Environ 285:89–95

    PubMed  Article  CAS  Google Scholar 

  26. Combs GF (2001) Selenium in global food systems. Br J Nutr 85:517–547

    PubMed  Article  CAS  Google Scholar 

  27. Pappa E, Pappas A, Surai P (2006) Selenium content in selected foods from the Greek market and estimation of the daily intake. Sci Total Environ 372:100–108

    PubMed  Article  CAS  Google Scholar 

  28. Bratakos MS, Ioannou PV (1991) Selenium in human milk and dietary selenium intake by Greeks. Sci Total Environ 105:101–107

    PubMed  Article  CAS  Google Scholar 

  29. Niskar AS, Paschal DC, Kieszak SM, Flegal KM, Bowman B, Gunter EW, Pirkle JL, Rubin C, Sampson EJ, McGeehin M (2003) Serum selenium levels in the US population. Biol Trace Elem Res 91:1–10

    PubMed  Article  CAS  Google Scholar 

  30. Arnaud J, Bertrais S, Roussel A, Arnault N, Ruffieux D, Favier A, Berthelin S, Estaquio C, Galan P, Czernichow S, Hercberg S (2006) Serum selenium determinants in French adults: the SU.VI.M.AX study. Brit J Nutr 95:313–320

    PubMed  Article  CAS  Google Scholar 

  31. Safaralizadeh R, Kardar GA, Pourpak Z, Moin M, Zare A, Teimourian S (2005) Serum concentration of selenium in healthy individuals living in Tehran. Nutr J 4:32–36

    PubMed  Article  CAS  Google Scholar 

  32. Hincal F, Başaran N, Yetgin S, Gökmen O (1994) Selenium status in Turkey. II. Serum selenium concentration in healthy residents of different ages in Ankara. J Trace Elem Electrolytes Health Dis 8:9–12

    PubMed  CAS  Google Scholar 

  33. Morisi G, Patriarca M, Marano G, Giampaoli S, Taggi F (1989) Age and sex specific reference serum selenium levels estimated for the Italian population. Ann Ist Super Sanita 25:393–403

    PubMed  CAS  Google Scholar 

  34. Deguchi Y, Ogata A (1991) Relationship between serum selenium concentration and Atherogenic Index in Japanese Adults, Tohoku. J Exp Med 165:247–251

    CAS  Google Scholar 

  35. Behne D, Hã-Fer-Bosse T (1984) Effects of a low selenium status on the distribution and retention of selenium in the rat. J Nutr 14:1289–1296

    Google Scholar 

  36. Behne D, Wolters W (1983) Distribution of selenium and glutathione peroxidase in the rat. J Nutr 13:456–461

    Google Scholar 

  37. Suzuki K, Kurasaki K, Okazaki N, Ogra Y (2005) Selenosugar and trimethylselenonium among urinary Se metabolites: dose- and age-related changes. Toxicol Appl Pharmacol 206:1–8

    PubMed  Article  CAS  Google Scholar 

  38. Rayman MP, Infante H, Sargent M (2008) Food-chain selenium and human health: spotlight on speciation. Br J Nutr 18:1–16

    Google Scholar 

  39. Schrauzer GN (2000) Selenomethionine: a review of its nutritional significance. Metabolism and toxicity. J Nutr 130:1653–1656

    PubMed  CAS  Google Scholar 

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Acknowledgments

The authors S.L. and S.A.P. thank the European Commission for the funding of a Marie Curie Excellence Grant (contact no. MEXT-CT-2003-002788).

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Authors and Affiliations

  1. Department of Science of Nutrition-Dietetics, Harokopio University, El. Venizelou 70, 17671, Athens, Greece

    Sophia Letsiou, Tzortzis Nomikos, Demosthenes Panagiotakos, Elizabeth Fragopoulou & Smaragdi Antonopoulou

  2. Department of Chemistry, University of Crete, Voutes, 71003, Heraklion, Crete, Greece

    Sophia Letsiou & Spiros A. Pergantis

  3. First Cardiology Clinic, School of Medicine, University of Athens, Vasilisis Sofias 114, 11527, Athens, Greece

    Christos Pitsavos & Christodoulos Stefanadis

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  1. Sophia Letsiou
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  2. Tzortzis Nomikos
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  3. Demosthenes Panagiotakos
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  4. Spiros A. Pergantis
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  5. Elizabeth Fragopoulou
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  6. Smaragdi Antonopoulou
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  7. Christos Pitsavos
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  8. Christodoulos Stefanadis
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Correspondence to Smaragdi Antonopoulou.

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Letsiou, S., Nomikos, T., Panagiotakos, D. et al. Serum Total Selenium Status in Greek Adults and Its Relation to Age. The ATTICA Study Cohort. Biol Trace Elem Res 128, 8 (2009). https://doi.org/10.1007/s12011-008-8252-2

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  • DOI: https://doi.org/10.1007/s12011-008-8252-2

Keywords

  • Serum selenium
  • Observational study
  • Nutrition
  • ICP-MS
  • Age
  • Adults