Oxidative Stress in Migraine with and Without Aura

Abstract

Migraine is the most common neurological disorder, but the molecular basis is still not completely understood. An impairment of mitochondrial oxidative metabolism might play a role in the pathophysiology. The goal of this study was to investigate the differences in oxidative stress status with the measurement of erythrocyte superoxide dismutase (SOD), catalase activity, and malondialdehyde (MDA) levels in the migraine patients with or without aura and attack. There were 56 patients (46 female, 10 male) in the migraine group and 25 matched healthy subjects in the control group. The patients comprised 37 with migraine without aura (MWoA], 19 with migraine with aura (MWA), and 22 with headache attack. The MDA levels of patients in the migraine group were significantly higher than that in the control group. The SOD activity was significantly higher in the MWA as compared to MWoA. There was no significant correlation between these levels and headache attack period. Conclusively, in this preliminary study, we had found increased oxidative stress in the migraine patients especially the patients with MWA. Further knowledge about this issue may contribute the cause and complications of migraine and may be essential for development of treatment approaches.

This is a preview of subscription content, access via your institution.

References

  1. 1.

    Goadsby PJ (2006) Recent advances in understanding migraine mechanisms, molecules and therapeutics. Trends Mol Med 13:39–44

    PubMed  Article  Google Scholar 

  2. 2.

    Schreiber CP (2006) The pathophysiology of migraine. Dis Mon 52:385–401

    PubMed  Article  Google Scholar 

  3. 3.

    Sparaco M, Feleppa M, Lipton RB, Rapoport AM, Bigal ME (2005) Mitochondrial dysfunction and migraine: evidence and hypotheses. Cephalalgia 26:361–372

    Article  Google Scholar 

  4. 4.

    Paravicini TM, Drummond GR, Sobey CG (2004) Reactive oxygen species in the cerebral circulation. Drugs 64:2143–2157

    PubMed  Article  CAS  Google Scholar 

  5. 5.

    Shimomura T, Kowa H, Nakano T et al (1994) Platelet superoxide dismutase in migraine and tension-type headache. Cephalalgia 14:215–218

    PubMed  Article  CAS  Google Scholar 

  6. 6.

    Thomsen LL, Olesen J (2001) Nitric oxide in primary headaches. Curr Opin Neurol 14:315–321

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    Tozzi-Ciancarelli MG, Matteis GD, Massimo CD, Marini C, Ciancarelli I, Carolei A (1997) Oxidative stress and platelet responsiveness in migraine. Cephalalgia 17:580–584

    PubMed  Article  CAS  Google Scholar 

  8. 8.

    Ciancarelli I, Tozzi-Ciancarelli MG, Massimo CD, Marini C, Carolei A (2003) Urinary nitric oxide metabolites and lipid peroxidation by-products in migraine. Cephalalgia 23:39–42

    PubMed  Article  CAS  Google Scholar 

  9. 9.

    Taffi R, Vignini A, Lanciotti C et al (2004) Platelet membrane fluidity and peroxynitrite levels in migraine patients during headache-free periods. Cephalalgia 25:353–358

    Article  Google Scholar 

  10. 10.

    Rejdak K, Empl M, Giffin NJ et al (2006) Increased urinary excretion of nitric oxide metabolites in longitudinally monitored migraine patients. Eur J Neurol 13:1346–1351

    PubMed  Article  CAS  Google Scholar 

  11. 11.

    Choudhuri R, Cui L, Yong C et al (2002) Cortical spreading depression and generegulation: relevance to migraine. Ann Neurol 51:499–506

    PubMed  Article  CAS  Google Scholar 

  12. 12.

    Parsons AA, Strijbos PJLM (2003) The neuronal versus vascular hypothesis of migraine and cortical spreading depression. Curr Opin Pharmacol 3:73–77

    PubMed  Article  CAS  Google Scholar 

  13. 13.

    Edvinsson L (2006) Neuronal signal substances as biomarkers of migraine. Headache 46:1088–1094

    PubMed  Article  Google Scholar 

  14. 14.

    Headache Classification Subcommittee of the International Headache Society (2004) The international classification of headache disorders: 2nd edition. Cephalalgia 24(1):9–160

    Google Scholar 

  15. 15.

    Fridovich I (1974) Superoxide dismutases. Adv Enzymol Relat Areas Mol Biol 41:35–97

    PubMed  Article  CAS  Google Scholar 

  16. 16.

    Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–358

    PubMed  Article  CAS  Google Scholar 

  17. 17.

    Beutler E (1975) Red Cell Metabolism. A Manual of Biochemical Methods, 2nd edn. Grune & Stratton, New York, pp 261–265

    Google Scholar 

  18. 18.

    Shukla R, Barthwal MK, Srivastava N et al (2004) Neutrophil-free radical generation and enzymatic antioxidants in migraine patients. Cephalalgia 24:37–43

    PubMed  Article  CAS  Google Scholar 

  19. 19.

    Bolayir E, Celik K, Kugu N, Yilmaz A, Topaktas S, Bakir S (2004) Intraerythrocyte antioxidant enzyme activities in migraine and tension-type headaches. J Chin Med Assoc 67:263–267

    PubMed  Google Scholar 

  20. 20.

    Bousser MG, Welch KA (2005) Relation between migraine and stroke. Lancet Neurol 4:533–542

    PubMed  Article  Google Scholar 

  21. 21.

    Agostoni E, Rigamonti A (2007) Migraine and cerebrovascular disease. Neurol Sci 28( 2):S156–S160

    PubMed  Article  Google Scholar 

  22. 22.

    Ciancarelli I, Tozzi-Ciancarelli MG, Massimo CD, Marini C, Carolei A (2004) Flunarizine effects on oxidative stress in migraine patients. Cephalalgia 24:528–532

    PubMed  Article  CAS  Google Scholar 

  23. 23.

    Linde M (2006) Migraine: a review and future directions for treatment. Acta Neurol Scand 114:71–83

    PubMed  Article  CAS  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Deniz Tuncel.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Tuncel, D., Tolun, F.I., Gokce, M. et al. Oxidative Stress in Migraine with and Without Aura. Biol Trace Elem Res 126, 92–97 (2008). https://doi.org/10.1007/s12011-008-8193-9

Download citation

Keywords

  • Migraine
  • Oxidative stress
  • SOD activity
  • Aura
  • Attack