Skip to main content
SpringerLink
Log in

Pharmacokinetic Study of Copper (II) Acetylsalicylate

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

This study was aimed at determination of pharmacokinetic parameters of copper (II) acetylsalicylate (CAS). Ten volunteers received a 60-mg dose of CAS. Blood samples were collected just before and after 0.25, 0.5, 0.75, 1.0, 1.5, 2.5, 3.0, 3.5, 4.0, 4.5, 5.5, 7.0, 10, and 12.0 h of administration of the drug. The plasma samples were analyzed for CAS and its metabolites by a validated high-performance liquid chromatography method having a suitable lower limit of quantification. The dose of 60 mg was well tolerated without any adverse effect. The maximum plasma concentration of CAS was found to be 0.38 mg L−1 with t max of 0.72 h. The plasma half-life, clearance, and volume of distribution of CAS were 8.67 h, 66.30 L h−1 and 829 L kg−1, respectively. The elimination of CAS, acetylsalicylic acid, copper salicylate, and salicylic acid follows the first order kinetics with r 2 0.979, 0.880, 0.991, and 0.998, respectively. The study provided for the first time the pharmacokinetic data for CAS after oral administration of CAS. The data were found to be useful in understanding the claimed enhanced anti-inflammatory activity of the drug as compared with that of acetylsalicylic acid.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Graham DY, Smith JL (1986) Aspirin and the stomach. Ann Intern Med 104(3):390–398

    PubMed  CAS  Google Scholar 

  2. Roderick PJ, Wilkes HC, Meade TW (1993) The gastrointestinal toxicity of aspirin: an overview of randomised controlled trials. Br J Clin Pharmacol 35(3):219–226

    PubMed  CAS  Google Scholar 

  3. Sorenson JRJ (1976) Copper chelates as possible active forms of the antiarthritic agents. J Med Chem 19(1):135–148

    Article  PubMed  CAS  Google Scholar 

  4. Sorenson JRJ (1978) Copper complexes—a unique class of antiarthritic drugs. Prog Med Chem 15:211–60 (review)

    Article  PubMed  CAS  Google Scholar 

  5. Medical News (1974) Copper boost activity of anti-inflammatory drugs. JAMA 229:1268–1269

    Google Scholar 

  6. Malkiel S, Har-el R, Schwalb H, Uretzky G, Borman JB, Chenion M (1993) Free Radic Res Commun 18(1):7–15

    Article  PubMed  CAS  Google Scholar 

  7. Mazzetti I, Grigolo B, Borzi RM, Meliconi R, Facchini A (1996) Int J Clin Lab Res 26(4):245–249

    Article  PubMed  CAS  Google Scholar 

  8. Tyrer LB (1984) Nutrition and the pill. J Reprod Med 29(7 Suppl):547–550

    PubMed  CAS  Google Scholar 

  9. Sorenson JRJ (1982) Inflammatory diseases and copper. Humana, Clifton, NJ

    Google Scholar 

  10. Borer LL, Barry E (2000) Experiments with aspirin. J Chem Educ 77:354

    Article  CAS  Google Scholar 

  11. Vinod P, Kamal K, John WA, Howard M, James D, Iain J, Rabindra N, Mark L, Alfred T, Viswanathan CT, Avraham Y (2000) Bioanalytical method validation—a revisit with a decade of progress. Pharm Res 17(12):1551–1557

    Article  Google Scholar 

  12. Buskin JN, Upton RA, Williams RL (1982) Improved liquid chromatography of aspirin, salicylate, and salicyluric acid in plasma, with a modification for determining aspirin metabolites in urine. Clin Chem 28(5):1200–1203

    PubMed  CAS  Google Scholar 

  13. Elliot CB, Lesley RL, Felix B, Debra MI (1980) Measurement and pharmacokinetics of acetylsalicylic acid by a novel high performance liquid chromatographic assay. Ther Drug Monit 2(4):365–372

    Google Scholar 

  14. Schwartz S, Paterman T. Pre-clinical pharmacokinetics. In: The comprehensive resource for physicians, drug and illness information. Available at: http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20A)/ASPIRIN.html

  15. Levy G (1978) Clinical pharmacokinetics of aspirin. Pediatrics 62(5):867–872

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, GC University, Lahore, Pakistan

    Mohammad S. Iqbal

  2. Department of Pharmacy, University of Sargodha, Sargodha, Pakistan

    Muhammad Sher

  3. Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan

    Muhammad Sher & Humayun Pervez

  4. Allama Iqbal Medical College, Lahore, Pakistan

    Maryiam Saeed

Authors
  1. Mohammad S. Iqbal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Muhammad Sher
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Humayun Pervez
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Maryiam Saeed
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mohammad S. Iqbal.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Iqbal, M.S., Sher, M., Pervez, H. et al. Pharmacokinetic Study of Copper (II) Acetylsalicylate. Biol Trace Elem Res 124, 283–288 (2008). https://doi.org/10.1007/s12011-008-8146-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12011-008-8146-3

Keywords

Search

Navigation