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The Role of Zinc in Thrombosis and Pulmonary Embolism in the Course of Antiphospholipid Syndrome (APS)—Short Review

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Abstract

Antiphospholipid antibodies may occur in the course of various diseases, but its presence is not necessarily associated with clinical symptoms. Zinc has multiple biological roles. For example, it stabilizes the cell’s membrane and regulates its functions by influencing the synthesis of phospholipids and its distribution. The present review focuses on the possible associations between zinc and antiphospholipid antibodies and with the symptoms of antiphospholipid syndrome.

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References

  1. Musiał J (2007) Antiphospholipid syndrome—a magnifying glass of medicine. Pol Arch Med Wew 117:41–43

    Google Scholar 

  2. Andree HAM, Reutelingsperger ChPM, Hauptmann R, Hemker HC, Hermes WTh, Willems GM (1990) Binding of vascular anticoagulant α (VCAα) to planar, phospholipids bilayers. J Biol Chem 265:4923–4928

    PubMed  CAS  Google Scholar 

  3. Vallee BL, Falchuk KH (1993) The biochemical basis of zinc physiology. Physiol Rev 73:79–87

    PubMed  CAS  Google Scholar 

  4. Kokot F, Tatoń J (1991) In: Kokot F. (ed.). Choroby Wewnętrzne, Zaburzenia przemiany materii, PZWL, Warszawa, p 670

  5. Holtmeier HJ, Kuhn M, Rummel K (1976) Zink ein lebenswichtiges Mineral. Wissenschaftliche Verlagsgeselschaft MbH, Stuttgart, p 13

    Google Scholar 

  6. Turner AJ, Brown CD, Carson JA, Barens K (2000) The neprilysin family in health and disease. Adv Exp Med Biol 477:229–240

    Article  PubMed  CAS  Google Scholar 

  7. Kulikowska E, Moniuszko-Jakoniuk J, Miniuk K (1991) Rola cynku w procesach fizjologicznych i patologicznych organizmu. Pol Tyg Lek 46:471–475

    Google Scholar 

  8. Cousins RJ (1986) Toward a molecular understanding of zinc metabolism. Clin Physiol Biochem 4:20–30

    PubMed  CAS  Google Scholar 

  9. O’Dell BL (2000) Role of zinc in plasma membrane function. J Nutr 130:1432S–1436S

    PubMed  CAS  Google Scholar 

  10. Avery RA, Bettger WJ (1992) Zinc deficiency alters the protein composition of the membrane skeleton but not the extractability or oligomeric form of spectrin in rat erythrocyte membranes. J Nutr 122:428–433

    PubMed  CAS  Google Scholar 

  11. Bettger WJ, O’Dell BL (1981) A critical physiological role of zinc in the structure and function of biomembranes. Life Sci 28:1425–1438

    Article  PubMed  CAS  Google Scholar 

  12. Carvalho A (1972) Binding and release of cations by sarcoplasmic reticulum before and after removal of lipids. Eur J Biochem 27:491–496

    Article  PubMed  CAS  Google Scholar 

  13. Driscoll ER, Bettger WJ (1992) Zinc deficiency in the rat alters the lipid composition of the erythrocyte membrane Triton shell. Lipids 27:972–977

    Article  PubMed  CAS  Google Scholar 

  14. Harrison NL, Radke HK, Tamkun MM, Lovinger DM (1993) Modulation of gating of cloned rat and human K + channels by micromolar Zn+2. Mol Pharmacol 43:482–490

    PubMed  CAS  Google Scholar 

  15. Heinemann SH, Struhnar W (1995) Molecular structure of potassium and sodium channels and their structure–function correlation. In: Nilins B, Droogmans G (eds) Ion channels of endothelial cells, 964. In: Sparelakis N (ed) Physiology and pathophysiology of the heart, 3rded., Kluwer Academic Publishers, Boston, Dortrecht, London, pp 109, 112

    Google Scholar 

  16. Maccara IG (1985) Oncogenesis, ions and phospholipids. Am J Physiol 248:C3–C8

    Google Scholar 

  17. Dorup I, Clausen T (1991) Effects of magnesium and zinc deficiencies on growth and protein synthesis in skeletal muscle and the heart. Br J Nutr 66:493–504

    Article  PubMed  CAS  Google Scholar 

  18. Csermely P, Somogyi J (1989) Zinc as a possible mediator of signal transduction in T lymphocytes. Acta Phys Hung 74:195–199

    CAS  Google Scholar 

  19. Csermely P, Sandor P, Radics L, Somogyi J (1989) Zinc forms complexes with higher kinetical stability than calcium, 5-F-BAPTA as a good example. Biochem Biophys Res Commun 165:838–843

    Article  PubMed  CAS  Google Scholar 

  20. Gordon PR, Woodruff CW, Anderson HL, O’Dell BL (1982) Effects of acute zinc deprivation on plasma zinc and platelet aggregation in adult males. Am J Clin Nutr 35:849–857

    Google Scholar 

  21. Hughes S, Samman S (2006) The effect of zinc supplementation in humans on plasma lipids, antioxidant status and thrombogenesis.. J Am Coll Nutr 25:285–291

    CAS  Google Scholar 

  22. Bernardo MM, Day DE, Olson ST, Halvorson HR, Shore JD (1993) Surface-independent acceleration of factor XII activation by zinc ions. I. Kinetic characterization of the metal ion rate enhancement. J Biol Chem 268:12468–12476

    PubMed  CAS  Google Scholar 

  23. Bernardo MM, Day DE, Olson ST, Halvorson HR, Shore JD (1993) Surface-independent acceleration of factor XII activation by zinc ions. II. Direct binding and fluorescence studies. J Biol Chem 268:12477–12483

    PubMed  CAS  Google Scholar 

  24. Van Nostrand WE (1995) Zinc (II) selectively enhances the inhibition of coagulation factor XIa by protease nexin-2/amyloid beta-protein precursor. Thromb Res 78:43–53

    Article  PubMed  Google Scholar 

  25. Mahdi F, Shariat-Madar Z, Schmaier AH (2005) The relative priority of prekallikrein and factors XI/XIa assembly on cultured endothelial cells. J Biol Chem 278:43983–43990

    Article  CAS  Google Scholar 

  26. Dębska A, Lelonek M (2005) The role of antiphospholipid antibodies in the pathogensis of acute coronary syndromes. Folia Cardiol 12:543–547

    Google Scholar 

  27. Kobayashi T, Beuchat M-H, Lindsay M, Frias S, Palmiter RD, Sakuraba H, Parton RG, Gruenberg J (1999) Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport. Nat Cell Biol 1:113–118

    Article  PubMed  CAS  Google Scholar 

  28. Lin YL, Wang CT (1992) Activation of human platelets by the rabbit anticardiolipin antibodies. Blood 80:3135–3143

    PubMed  CAS  Google Scholar 

  29. Bevers EM, Comfurius P, Dekkers DW, Harmsma M, Zwaal RF (1998) Regulatory mechanisms of transmembrane phospholipids distributions and pathophysiological implications of transbilayer lipid scrambling. Lupus 7(suppl 2):S126–S131

    PubMed  CAS  Google Scholar 

  30. Johanning GL, O’Dell BL (1989) Effect of zinc deficiency and food restriction in rats on erythrocyte membrane zinc, phospholipids and protein content. J Nutr 119:1654–1660

    PubMed  CAS  Google Scholar 

  31. Verstraeten SV, Zago MP, MacKenzie GG, Keen CL, Oteiza PI (2004) Influence of zinc deficiency on cell-membrane fluidity in Jurkat, 3T3 and IMR-32 cells. Biochem J 378:579–587

    Article  PubMed  CAS  Google Scholar 

  32. Wang X, Kaetzel MA, Yoo SE, Kim PS, Dedman JR (2002) Ligand-regulated secretion of recombinant annexin V from cultured thyroid epithelial cells. Am J Physiol Cell Physiol 282:C1313–C1321

    PubMed  CAS  Google Scholar 

  33. Zhang J, McCrae KR (2005) Annexin A2 mediates endothelial cell activation by antiphospholipid/anti-β2 glycoprotein I antibodies. Blood 105:1964–1969

    Article  PubMed  CAS  Google Scholar 

  34. Carman GM (2005) Regulation of phospholipids synthesis in yeast by zinc. Biochem Soc Trans 33:1150–1153

    Article  PubMed  CAS  Google Scholar 

  35. Iwanyshyn WM, Han GS, Carman GM (2004) Regulation of phospholipids synthesis in Saccharomyces cerevisiae by zinc. J Biol Chem 279:21976–21983

    Article  PubMed  CAS  Google Scholar 

  36. Gabryelak T, Akahori A, Przybylska M, Jóźwiak Z, Brichon G (2002) Carp erythrocyte lipids as a potential target for the toxic action of zinc ions. Toxicol Lett 132:57–64

    Article  Google Scholar 

  37. Wiseman DA, Wells SM, Wilham J, Hubbard M, Welker JE, Black SM (2006) Endothelial response to stress from exogenous Zn2 + resembles that of NO-mediated nitrosative stress, and is protected by MT-1 overexpression. Am J Physiol Cell Physiol 291:C555–C568

    Article  PubMed  CAS  Google Scholar 

  38. Zago MP, Verstraeten SV, Oteiza PI (2000) Zinc in the prevention of Fe2 +-initiated lipid and protein oxidation. Biol Res 33:143–150

    Article  PubMed  CAS  Google Scholar 

  39. Tao J, Yang Z, Wang JM, Luo CF, Tang AL, Dong GY, Ma H (2007) Shear stress increases Cu/Zn SOD activity and mRNA expression in human endothelial progenitor cells. J Hum Hypertens 21:353–358

    Article  PubMed  CAS  Google Scholar 

  40. Bagi Z, Hamar P, Kardos M, Koller A (2006) Lack of flow-mediated dilation and enhanced angiotensin II- induced constriction in skeletal muscle arterioles of lupus-prone autoimmune mice. Lupus 15:326–334

    Article  PubMed  CAS  Google Scholar 

  41. Gomez NN, Ojeda MS, Gimenez MS (2002) Lung lipid composition in zinc-deficient rats. Lipids 37:291–296

    Article  PubMed  CAS  Google Scholar 

  42. Beatty AL, Malloy JL, Wright JR (2005) Pseudomonas aeruginosa degrades pulmonary surfactant and increases conversion in vitro. Am J Respir Cell Mol Biol 32:128–134

    Article  PubMed  CAS  Google Scholar 

  43. Sanaka T, Matsuda J, Teramoto T (2003) Detection and clinical significance of Ba2 +- and Sr2 +-dependent antiprothrobmin antibodies in patients with systemic lupus erythematosus and antiphospholipid syndrome. Lupus 12:117–123

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Faculty of Physical Education and Physiotherapy, Institute of Technology, Prószkowska Street 76, 45-758, Opole, Poland

    Sławomir Tubek & Iwona Tubek

  2. Department of Internal Diseases, University Hospital of Collegium Medicum, Jagiellonian University, Kraków, Poland

    Piotr Grzanka

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  1. Sławomir Tubek
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  2. Piotr Grzanka
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  3. Iwona Tubek
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Correspondence to Sławomir Tubek.

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Tubek, S., Grzanka, P. & Tubek, I. The Role of Zinc in Thrombosis and Pulmonary Embolism in the Course of Antiphospholipid Syndrome (APS)—Short Review. Biol Trace Elem Res 122, 193–196 (2008). https://doi.org/10.1007/s12011-007-8077-4

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  • DOI: https://doi.org/10.1007/s12011-007-8077-4

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