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Moderate Accumulation of Calcium and Phosphorus in the Splenic Artery with Aging and Low Accumulation of Those in the Pulmonary Artery with Aging

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Abstract

To elucidate compositional changes of the arteries with aging, the authors investigated age-related changes of elements in the splenic and pulmonary arteries, which supplied blood to contractile organs. After ordinary dissection by medical students at Nara Medical University was finished, the splenic and pulmonary arteries were resected from the subjects, ranging in age from 58 to 94 years. The element contents were determined by inductively coupled plasma-atomic emission spectrometry. It was found that a moderate accumulation of Ca and P occurred in the splenic artery with aging, but it hardly occurred in the pulmonary artery with aging. Regarding the relationship among elements, the finding that there were significant direct correlations among the contents of Ca, P, Mg, and Na was commonly obtained in both the splenic and pulmonary arteries. The accumulation of Ca and P in the splenic artery with aging occurred independently of that in the pulmonary artery. Histologic observation indicated that a major part of Ca deposits was seen in the middle tunica, but not in the internal tunica. Therefore, the calcification occurring in the splenic artery belonged to middle sclerosis.

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Acknowledgment

Portions of this work were supported by a Grant-in-Aid for Scientific Research no. 17200032 from Japan Society for the Promotion of Science.

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Authors and Affiliations

  1. Laboratory of Cell Biology, Department of Anatomy, Nara Medical University School of Medicine, Kashihara, Nara, 634-8521, Japan

    Iria Maria Prieto Payo, Nutcharin Ongkana, Setsuko Tohno, Cho Azuma, Yumi Moriwake & Yoshiyuki Tohno

  2. Santiago de Compostela University, Monforte de Lemos, Lugo, 27400, Spain

    Iria Maria Prieto Payo

  3. Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand

    Nutcharin Ongkana

  4. Laboratory of Environmental Biology, Department of Life Science, Faculty of Science and Engineering, Kinki University, Higashi-Osaka, Osaka, 577-8502, Japan

    Takeshi Minami

Authors
  1. Iria Maria Prieto Payo
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  2. Nutcharin Ongkana
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  3. Setsuko Tohno
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  4. Cho Azuma
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  5. Takeshi Minami
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  6. Yumi Moriwake
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  7. Yoshiyuki Tohno
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Correspondence to Yoshiyuki Tohno.

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Prieto Payo, I.M., Ongkana, N., Tohno, S. et al. Moderate Accumulation of Calcium and Phosphorus in the Splenic Artery with Aging and Low Accumulation of Those in the Pulmonary Artery with Aging. Biol Trace Elem Res 119, 103–110 (2007). https://doi.org/10.1007/s12011-007-0052-6

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  • DOI: https://doi.org/10.1007/s12011-007-0052-6

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