Abstract
India is considered a hub for a wide range of phytochemicals due to its rich biodiversity, which indeed flourished with many folk medicines and treatments. Phytochemicals are secondary metabolites synthesized in plants to protect themselves from deteriorating environmental stress and defense against pathogens. In the present study, we aimed to explore the strong anticancer potential of the bioactive compound present in the leaf extract of Coldenia procumbens (L.). The bioactive compound oleanolic acid was first time reported in the plant and was successfully isolated, characterized with various spectroscopic analyses. The in vitro study results explored that oleanolic acid has shown a potent cytotoxic effect against human hepatocellular carcinoma cell lines with a low IC50 value (40.66μg/mL) and induced apoptotic cell death. Overall, the present findings clearly demonstrated that the natural triterpenoid compound oleanolic acid isolated from C. procumbens showed a potent cytotoxic effect against HepG2 cells and explored the strong anticancer potential against liver cancer.
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Acknowledgements
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Our sincere gratitude to the Head of the Department of Biotechnology, University of Madras, Guindy Campus, Chennai, for providing valuable suggestions and space to carry out my research.
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Sincere thanks to Dr. S. Vinod Kanna, Department of Botany, and the Head, School of Science, Tamil Nadu Open University, to carry out my proceedings for the paper.
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Prof. S. Elumalai and Dr. R. Banupriya equally contributed for full research ideas, work, and development of the scientific paper. Dr. G.K. Saravanan helped for preliminary study in sample collection and characterization. Dr. P. Parthasarathi helped for the cell line studies.
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Ravichandran, B., Sanniyasi, E., Govindasamy Kuppusamy, S. et al. Onco-therapeutic Effect of Novel Triterpenoid Compound Oleanolic Acid Isolated and Characterized from the Methanolic Extract of Coldenia procumbens (Linn.). Appl Biochem Biotechnol (2024). https://doi.org/10.1007/s12010-024-04959-7
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DOI: https://doi.org/10.1007/s12010-024-04959-7