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Analysis of Correlation Between LncRNA TDRG1 Expression and its Prognosis in Cervical Carcinoma Tissues

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Abstract

To explore and analyze the correlation between LncRNA TDRG1 expression degree and the prognosis of cervical carcinoma tissues. The cervical cancer tissues and para-carcinoma tissues of 106 patients with cervical carcinoma surgically removed in our hospital were chosen as specimens. LncRNA TDRG1 expression in cervical carcinoma tissues and para-carcinoma tissues was inspected by real-time fluorescence quantitative PCR, and the correlation between LncRNA TDRG1 and the clinicopathological parameters and disease prognosis was analyzed. The relative expression of LncRNA TDRG1 in cervical carcinoma tissues was critically gone up (P < 0.05) compared to para-carcinoma tissues. The relative expression of LncRNA TDRG1 in cervical carcinoma was correlated with FIGO staging, lymph node metastasis, infiltrating depth of cervical basal, and the differentiation of cancer cells (P < 0.05). According to the results of the Kaplan–Meier curve and Log-rank test, the overall survival conditions of subjects with low-lncRNA TDRG1 were superior to that of those with high-lncRNA TDRG1 expression (P < 0.05). The expression of LncRNA TDRG1 in cervical carcinoma tissues and the clinicopathological features in predicting the overall survival (OS) in sufferers with cervical carcinoma were investigated by the Cox regression model. LncRNA TDRG1 expression in cervical carcinoma tissues is tightly associated with the progression and prognosis of cervical carcinoma, which may be a latent biological indicator for clinical diagnosis and prognosis of cervical carcinoma.

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Authors and Affiliations

  1. Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm-Alqura University, Mecca, Saudi Arabia

    Amal Ezzat Abd El-Lateef, Adel Galal Ahmed El-Shemi, Raafat Abdel Moneim Hassanein & Mohammad shahid Iqbal

  2. Department of Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt

    Amal Ezzat Abd El-Lateef

  3. Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt

    Adel Galal Ahmed El-Shemi

  4. Department of Zoonoses, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt

    Raafat Abdel Moneim Hassanein

  5. College of Medicine, King Abdulaazzi Bin University, Riyadh, Saudi Arabia

    Shatha Abdullah Albloshi

  6. Department Family and Community Medicine, College of Medicine - King Saud University, Riyadh, Saudi Arabia

    Shatha Abdullah Albloshi

Authors
  1. Amal Ezzat Abd El-Lateef
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  2. Adel Galal Ahmed El-Shemi
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  3. Raafat Abdel Moneim Hassanein
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  4. Mohammad shahid Iqbal
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  5. Shatha Abdullah Albloshi
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Contributions

AEAE, AGAES, and SAA – concepts, design, data analysis, statistical analysis, manuscript preparation, manuscript review, guarantor.

AEAE, RAMH, MSI – definition of intellectual content, literature search, experimental studies, data acquisition, manuscript editing.

Corresponding authors

Correspondence to Amal Ezzat Abd El-Lateef or Shatha Abdullah Albloshi.

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Ethical Approval

Ethical approval was obtained from the Institutional Ethical review board (IEC) of the Faculty of Applied Medical Sciences, Umm-Alqura University, Mecca, Saudi Arabia.

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Informed consent was obtained from the participants with the option to withdraw from the study at any time.

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IEC, Faculty of Applied Medical Sciences, Umm-Alqura University, Mecca, Saudi Arabia, approved the publication of data generated from this study.

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The authors declare no competing interest.

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El-Lateef, A.E.A., El-Shemi, A.G.A., Hassanein, R.A.M. et al. Analysis of Correlation Between LncRNA TDRG1 Expression and its Prognosis in Cervical Carcinoma Tissues. Appl Biochem Biotechnol 196, 1079–1088 (2024). https://doi.org/10.1007/s12010-023-04496-9

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  • DOI: https://doi.org/10.1007/s12010-023-04496-9

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