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An Overview of Collagen-Based Composite Scaffold for Bone Tissue Engineering

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Abstract

Bone regeneration or restoration is a series of well-ordered physiological activities that occur throughout a person’s life, they are continuously being repaired and remodeled. A conventional bone repair procedure, such as autograft and allograft bone transplant, has failed to address bone reconstruction disputes and complexity. On the other hand, Tissue Engineering is a potential therapy option for repairing rather than replacing the damaged tissue. Biomaterials in bone tissue engineering (BTE) help pave the way for damaged tissues as an artificial extracellular matrix, facilitating new tissue growth. Collagen-based biomaterials for repair and replacement have inspired much interest in the hunt for versatile biomaterials compatible with human tissue. It is a major organic component of extracellular matrix in bone and has been employed as scaffolding material in BTE for decades. In this review, we documented the role of collagen in BTE, focusing on collagen type I, its crosslinking capability, collagen-based biomaterials, and fabrication methods. It also considers osteoblast citration a critical process in bone formation, a unique perspective for an old relationship.

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Authors and Affiliations

  1. School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, India

    Ashwathi Vijayalekha & Ashok Kumar Pandurangan

  2. Biochemistry & Biotechnology Laboratory, CSIR-Central Leather Research Institute, Adyar, Chennai, India

    Suresh Kumar Anandasadagopan

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All authors contributed to the study conception. The first draft of the manuscript was written by Ashwathi Vijayalekha; review and editing was done by Suresh Kumar Anandasadagop. All authors read and approved the final manuscript.

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Vijayalekha, A., Anandasadagopan, S.K. & Pandurangan, A.K. An Overview of Collagen-Based Composite Scaffold for Bone Tissue Engineering. Appl Biochem Biotechnol 195, 4617–4636 (2023). https://doi.org/10.1007/s12010-023-04318-y

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