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An Increase in Admission RDW Value Is Associated with Excess Short-Term Mortality Rates in Patients with Severe Burns

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Abstract

The predictive value of red blood cell distribution width (RDW) in severely burned patients remains unclear. This study aimed to investigate the potential association between admission RDW and outcomes in patients with severe burns. Data of severely burned patients in the burn center of Changhai Hospital were retrospectively evaluated. The relationship between admission RDW and mortality was analyzed and displayed using the receiver operating characteristic curve, Kaplan–Meier curve, Cox proportional hazards regression, and the nomogram method. A total of 342 patients were identified according to the filter criteria. The 30-day mortality was 12.9%, and the mortality rates in 7 days and 90 days were 2.9% and 16.7%, respectively. Patients with high admission RDW value were more likely to die than those with low RDW value. Multivariate analysis revealed that higher admission RDW, age, full-thickness burned area, and inhalation injury were independent risk factors with 30-day mortality. The nomogram based on these risk factors was established to predict survival probability in severe burn patients. The C-index of different follow-up times was computed between 0.867 and 0.904, and the nomogram model list fits the data well. Admission RDW played a valuable role in predicting short-term mortality in patients with severe burns. The nomogram containing admission RDW was established to predict mortality, which helps burn care providers identify the patients at higher risk of short-term mortality after severe burns. More attention should be paid to the application of these easy and inexpensive biochemical indicators in the early prediction of disease progression.

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Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We would acknowledge the whole maintenance staff of electronic medical record system.

Funding

This work was supported by the foundation of Shanghai hospital development center (SHDC2020CR4100).

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Author notes

  1. Honghao Lai, Zhuhong Cai, and Shengyong Wu contributed equally to this work.

Authors and Affiliations

  1. Department of Burn, Changhai Hospital, Naval Medical University, Shanghai, 200433, China

    Honghao Lai, Wei Zhang & Guosheng Wu

  2. Department of Burn, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, China

    Honghao Lai

  3. Department of Ultrasonography, Changhai Hospital, Naval Medical University, Shanghai, 200433, China

    Zhuhong Cai

  4. Department of Military Health Statistics, Naval Medical University, Shanghai, 200433, China

    Shengyong Wu

  5. Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, China

    Jiali Chen

Authors
  1. Honghao Lai
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  4. Wei Zhang
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Contributions

All authors have got final approval of the manuscript and agreed to be accountable for all aspects of the work.

Research scheme design: Guosheng Wu.

Data collection: Honghao Lai, Zhuhong Cai, Shengyong Wu, Wei Zhang, Jiali Chen.

Data Analyze: Honghao Lai, Zhuhong Cai, Shengyong Wu.

Article written: Guosheng Wu, Honghao Lai, Zhuhong Cai.

Manuscript proofread: Guosheng Wu.

Manuscript revised: Guosheng Wu.

Corresponding author

Correspondence to Guosheng Wu.

Ethics declarations

Research Ethics and Informed Consent

This retrospective study was approved by the Medical Ethics Committee of Changhai Hospital of Naval Medical University. At the same time, our study did not affect the normal treatment of patients. All the patients’ privacy information would be kept confidential.

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The authors declare no competing interests.

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Lai, H., Cai, Z., Wu, S. et al. An Increase in Admission RDW Value Is Associated with Excess Short-Term Mortality Rates in Patients with Severe Burns. Appl Biochem Biotechnol 195, 3217–3228 (2023). https://doi.org/10.1007/s12010-022-04302-y

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  • DOI: https://doi.org/10.1007/s12010-022-04302-y

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