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Phytocompounds From Edible Oil Seeds Target Hub Genes To Control Breast Cancer

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Abstract

Breast cancer is one of the most commonly diagnosed cancers in woman which accounts for more than 1 in 10 new cancers in the entire world. The recently found four new potential hub genes that show a strong expression in breast cancer are CCNA2, CCNB1, MAD2L1, and RAD51. Nowadays, food habits and lifestyle of an individual are one of the factors for causing cancers. Consumption of seeds on a regular basis is the key factor for leading a good health. Sesame seeds and Sunflower seeds are few examples of cancer fighting seeds. Sesame (Sesamum indicum) is one of the earliest oil seed plant with various phytocompounds present which include lignans, tocopherols, phenolics, polyunsaturated fatty acids, and phytosterols. Sunflower (Helianthus annuus L.) is primarily harvested as an oil seed plant with various phytocompounds present which include flavonoids, phenolic acids, tocopherols, and vitamin B3. These are the few seeds that help women to prevent and also to fight against Breast cancer with its potential anti-cancer activity. The main objective of the current study is to identify the potential phytocompounds present in the cancer fighting seeds using molecular docking and dynamic simulation approach which can further help pharmaceuticals industries in producing targeted drugs against breast cancer hub genes as well as food industries in producing products combining the potential phytocompounds present in the seeds.

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Acknowledgements

The authors are very much grateful to School of Life Sciences, B S Abdur Rahman Crescent Institute of Science and Technology, Chennai, for providing research facilities and also for their constant support and encouragement.

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  1. School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science & Technology, Tamil Nadu, Vandalur, Chennai, 600048, India

    Soniya Ashok Kumar, Noorul Samsoon Maharifa Haja Mohaideen & Hemalatha S

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  1. Soniya Ashok Kumar
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  2. Noorul Samsoon Maharifa Haja Mohaideen
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  3. Hemalatha S
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SH conceived and designed research. SA and NS conducted experiments and analyzed data. All authors wrote the manuscript. All authors read and approved the manuscript.

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Correspondence to Hemalatha S.

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Kumar, S.A., Mohaideen, N.S.M.H. & S, H. Phytocompounds From Edible Oil Seeds Target Hub Genes To Control Breast Cancer. Appl Biochem Biotechnol 195, 1231–1254 (2023). https://doi.org/10.1007/s12010-022-04224-9

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