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Myconanoparticles Break Antibiotic Resistance in Staphylococcus aureus and Acinetobacter baumannii

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Abstract

In this current study, the extracts of endophytic fungi (Aspergillus niger) were utilized to synthesize the silver nanoparticles (AnNps). In silico screening was carried out by docking secondary metabolites of Aspergillus niger with drug-resistant proteins such as penicillin-binding protein (pbp2a) and clumping factor A of Staphylococcus aureus, penicillin-binding protein (PBP3), and outer membrane protein of Acinetobacter baumannii. The molecular docking analysis revealed the interaction between secondary metabolites of Aspergillus niger with virulence factors of the pathogenic bacteria. AnNps are characterized by various physicochemical methods to determine the size, shape, and stability. Antibacterial efficacy of synthesized nanoparticles (AnNps) was screened in clinical pathogens. AnNp treatment significantly reduced the growth of MDR pathogens. The results suggested that AnNps can be incorporated to produce antimicrobial agents to control drug resistant pathogenic bacteria.

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References

  1. Akther, T., Khan, M. S., & Hemalatha, S. (2020). Journal of Environmental Chemical Engineering, 8(6), 104365.

    Article  CAS  Google Scholar 

  2. Bagheri, G., Martorell, M., Ramírez-Alarcón, K., Salehi, B., & Sharifi-Rad, J. (2020). Phytochemical screening of Moringa oleifera leaf extracts and their antimicrobial activities. Cell Mol Biol (Noisy-le-grand), 66(1), 20–26.

    Article  Google Scholar 

  3. Castillo-Henríquez, L., Alfaro-Aguilar, K., Ugalde-Álvarez, J., Vega-Fernández, L., de Montes Oca-Vásquez, G., & Vega-Baudrit, J. R. (2020). Nanomaterials (Basel, Switzerland), 10(9), 1763.

    Article  Google Scholar 

  4. Akther, T., Ranjani, S., & Hemalatha, S. (2021). Environmental Sciences Europe, 33, 83.

    Article  CAS  Google Scholar 

  5. Basheerudeen, M.A., Mushtaq, S., Soundhararajan, R., Nachimuthu, S.K., and Srinivasan, H. (2020). 11(11):2901

  6. Nielsen, K. F., Mogensen, J. M., Johansen, M., Larsen, T. O., & Frisvad, J. C. (2009). Analytical and Bioanalytical Chemistry, 395(5), 1225–1242.

    Article  CAS  Google Scholar 

  7. Anitha, S, Ranjani, S, Hemalatha, S, (2021) Biointeraface. 11 (5).

  8. Abarca, M. L., Bragulat, M. R., Castellá, G., & Cabañes, F. J. (1994). Applied and Environment Microbiology, 60(7), 2650–2652.

    Article  CAS  Google Scholar 

  9. Abhishek Kumar Verma, Sk. Faisal Ahmed, Md. Shahadat Hossain, Ali Asger Bhojiya, Ankita Mathur, Sudhir K. Upadhyay, Abhishek K. Srivastava, Naveen Kumar Vishvakarma, Mayadhar Barik, Md. Mizanur Rahaman and Newaz Mohammed Bahadur (2021) , J. Biomol. Struct. Dyn. 1–17

  10. Verma, A. K., Ahmed, S. F., Hossain, M. S., Bhojiya, A. A., Mathur, A., Upadhyay, S. K., Srivastava, A. K., Vishvakarma, N. K., Barik, M., Rahaman, M. M., and Bahadur, N. M. (2021) , J. Biomol. Struct. Dyn. 1–17.

  11. Skariyachan, S., Manjunath, M., & Bachappanavar, N. (2019). Journal of Biomolecular Structure & Dynamics, 37(5), 1146–1169.

    Article  CAS  Google Scholar 

  12. Nie, D., Hu, Y., Chen, Z., Li, M., Hou, Z., Luo, X., Mao, X., & Xue, X. (2020). Journal of Biomedical Science, 27(1), 26.

    Article  CAS  Google Scholar 

  13. Ravindranath, K. J., Mohaideen, N., & Srinivasan, H. (2022). Applied biochemistry and biotechnology. https://doi.org/10.1007/s12010-022-04016-1 Advance online publication.

    Article  Google Scholar 

  14. Mendie, L. E., & Hemalatha, S. (2022). Applied biochemistry and biotechnology, 194(1), 215–231. https://doi.org/10.1007/s12010-021-03791-7

    Article  CAS  Google Scholar 

  15. Jemmy Christy, H., Vasudevan, S., Sudha, S., Kandeel, M., Subramanian, K., Pugazhvendan, S. R., Ronald Ross, P., & Velmurugan (2022). BioMed research international, 2022, 6600403. https://doi.org/10.1155/2022/6600403

  16. Bush, K., & Bradford, P. A. (2016). Cold Spring Harbor Perspectives in Medicine, 6(8), a025247.

    Article  Google Scholar 

  17. Nithin J, C. Ranjani, S. Hemalatha, S. (2022). Appl Biochem Biotechnol 1559–0291.

  18. Khan, S. U., Anjum, S. I., Ansari, M. J., Ullah Khan, M. H., Kamal, S., Rahman, K., Shoaib, M., Man, S., Khan, A. J., Khan, S. J., & Khan, D. (2019). Saudi. Journal of Biological Sciences, 26, 1815–1834.

    CAS  Google Scholar 

  19. Khan, M. S., Ranjani, S., & Hemalatha, S. (2022). Mater Chem Phys, 282, 125985. ISSN 0254–0584.

    Article  CAS  Google Scholar 

  20. Jayaprakash, R., Sha, S. K., Hemalatha, S., & Easwaramoorthy, D. (2016). Asian Journal of Pharmaceutical and Clinical Research, 9(9), 203–208.

    Article  CAS  Google Scholar 

  21. Ranjani, S. S., Ahmed, M., MubarakAli, D., Ramachandran, C. S., Kumar, N., & Hemalatha, S. (2021). Inorg Nano-Met Chem, 51(8), 1080–1085.

    Article  Google Scholar 

  22. Ranjani, S. Abdul Matheen. Antony Jenish. A. and Hemalatha, S. (2021a).Mater. Lett. 304.

  23. Ranjani, S. F., Begum, I., Santhoshini, J. S., Kumar, N., Ruckmani, K., & Hemalatha, S. (2021). Inorg Nano-Met Chem, 51(12), 1751–1758.

    CAS  Google Scholar 

  24. Ranjani, S. Mohamed Sheik Meeran, S. Prakash, S. P. Mohammad, W. Kandasamy, R. and Hemalatha, S. (2020). AMB Express, 10(1), 168.

  25. Ranjani, S., & Pradeep, P. (2021). Vimalkumar, U, Ramesh Kumar, V and Hemalatha, S. Aquaculture International, 29, 859–869.

    Google Scholar 

  26. CharlzNithin, J. (2022). Ranjani Soundhararajan, Hemalatha Srinivasan. Appl BiochemBiotechnol, 194, 3066–3081. https://doi.org/10.1007/s12010-022-03882-z

    Article  CAS  Google Scholar 

  27. Manaal Sheerin Khan, Ranjani S, Hemalatha S, (2022), Materials Chemistry and Physics, Volume 282.

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Acknowledgements

Authors are thankful to B.S. Abdur Rahman Institute of Science and Technology, Chennai, for providing research facilities in school of life sciences. The authors also gratefully acknowledge the Ministry of Science and Technology, Department of Science and Technology (KIRAN Division) (GoI), New Delhi (Ref No. DST/WOS-B/2018/1583-HFN (G)).

Funding

This study is funded by the Ministry of Science and Technology, Department of Science and Technology (KIRAN Division) (GoI), New Delhi (Ref No. DST/WOS-B/2018/1583-HFN (G)).

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Author notes

  1. S Janarthanan and S Ranjani have equal contribution.

Authors and Affiliations

  1. School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamil Nadu, 600048, India

    S. Janarthanan, S. Ranjani & S. Hemalatha

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  1. S. Janarthanan
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  2. S. Ranjani
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  3. S. Hemalatha
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Contributions

SH conceived and designed research. SJ and SR conducted experiments. SH analyzed data. All authors wrote the manuscript. All authors read and approved the manuscript.

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Correspondence to S. Hemalatha.

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Janarthanan, S., Ranjani, S. & Hemalatha, S. Myconanoparticles Break Antibiotic Resistance in Staphylococcus aureus and Acinetobacter baumannii. Appl Biochem Biotechnol 195, 196–216 (2023). https://doi.org/10.1007/s12010-022-04125-x

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