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Oxygen- and Sulphur-Containing Heterocyclic Compounds as Potential Anticancer Agents

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Abstract

Oxygen- and sulphur-based heterocycles form the core structure of many biologically active molecules as well as U.S. FDA-approved drugs. Moreover, they possess broad range of biological activities, viz. anticancer, antiinflammatory, antioxidant, antitumour, antibacterial, antiviral, antidiabetic, anticonvulsant, anti-tubercular, analgesic, anti-leishmanial, antimalarial, antifungal, and anti-histaminic, Hence, O- and S-based heterocycles are gaining more attention in recent years on the road to the discovery of innovative anticancer drugs after the extensive investigation of nitrogen-based heterocycles as anticancer agents. Several attempts have been made to synthesize fused oxygen- and sulphur-based heterocyclic derivatives as joining one heterocyclic moiety with another may lead to improvement in the biological profile of a molecule. Humans have been cursed with cancer since long time. Despite the development of several heterocyclic anticancer medications such as 5-fluorouracil, doxorubicin, methotrexate, and daunorubicin, cure of cancer is difficult. Hence, researchers are trying to synthesize new fused/spiro heterocyclic molecules to discover novel anticancer drugs which may show promising anticancer effects with fewer side effects. Furthermore, fused heterocycles behave as DNA intercalating agents which have the ability to interact with DNA, leading to cell death thereby exerting anticancer effect. This review article highlights the synthesis and anticancer potentiality of oxygen- and sulphur-containing heterocyclic compounds covering the period from 2011 to 2021.

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Acknowledgements

The authors are thankful to the Head, Department of Chemistry, University of Rajasthan, Jaipur, Rajasthan, India, for providing necessary research facilities in the department.

Funding

Financial support to three authors Abhinav Raj Khandelwal (file no: 09/149(0813)/2020-EMR-I), Ravina Meena (file no: 09/149(0804)/2020-EMR-I), Narsingh Khatik (file no: 09/149 (0802)/2020-EMR-I) from CSIR, New Delhi, is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, University of Rajasthan, 302004, Jaipur, Rajasthan, India

    Harshita Sachdeva, Narsingh Khatik, Abhinav Raj Khandelwal, Ravina Meena & Khushboo Sharma

  2. Department of Chemistry, School of Liberal Arts and Sciences, Mody University of Science and Technology, Lakshmangarh (Sikar), Rajasthan, India

    Sarita Khaturia

  3. Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, India

    Mohammad Saquib

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  1. Harshita Sachdeva
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Contributions

Harshita Sachdeva has been involved in study conception, design, and in writing final draft of the manuscript and revising it critically for important intellectual content.

Sarita Khaturia has made substantial contributions to study conception and design, drafting the manuscript, acquisition, and interpretation of data.

Mohammad Saquib has contributed substantially to material preparation, acquisition of data, and analysis.

Narsingh Khatik has contributed to material preparation, data collection, and analysis.

Abhinav Raj Khandelwal has contributed to material preparation, data collection, and analysis.

Ravina Meena has contributed to material preparation, data collection, and analysis.

Khushboo Sharma has contributed to material preparation, data collection, and analysis.

All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Harshita Sachdeva.

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Sachdeva, H., Khaturia, S., Saquib, M. et al. Oxygen- and Sulphur-Containing Heterocyclic Compounds as Potential Anticancer Agents. Appl Biochem Biotechnol 194, 6438–6467 (2022). https://doi.org/10.1007/s12010-022-04099-w

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