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Alpinetin: a Dietary Flavonoid with Diverse Anticancer Effects

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Abstract

Cancer is  a global burden and mechanistically complex disease with a plethora of genetic, physiological, metabolic, and environmental alterations. The development of dietary nutraceuticals into cancer chemotherapeutics has emerged as a new paradigm in cancer treatment. Alpinetin (ALPI) is a novel flavonoid component of multiple edible and medicinal plants and possesses a wide range of biological and pharmacological activities including antibacterial, anti-hemostatic, anti-oxidative, anti-hepatotoxic, stomachic, immunosuppressive, and anti-inflammatory. Recently, ALPI has been reported as a bioactive dietary nutraceutical with promising anticancer activity in various human cancers through multiple mechanisms. The purpose of this review is to compile the data on natural sources of ALPI, and its anticancer activity including cellular targets and anticancer mechanism in various human cancers. Moreover, this review will set the stage for further design and conduct pre-clinical and clinical trials to develop ALPI into a lead structure for oncological therapy.

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Funding

This study was supported by the National Natural Science Foundation of China (Grant No.81672944), the priority academic program, development of Jiangsu Higher Education Institutions (Integration of Chinese and Western Medicines) and Innovation team of Six Talent Peaks Project in Jiangsu Province (WSN-062).

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  1. Sameena Gul and Muhammad Faisal Maqbool contributed equally to this work.

Authors and Affiliations

  1. School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China

    Sameena Gul, Yongming Li & Tonghui Ma

  2. Institute of Zoology, University of the Punjab, Quaid-E-Azam Campus, Lahore, 54590, Pakistan

    Sameena Gul, Muhammad Faisal Maqbool & Muhammad Khan

  3. Department of Obstetrics and Gynecology, Second Affiliated Hospital of Dalian Medical University, Dalian, China

    Dongying Zheng

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  1. Sameena Gul
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  2. Muhammad Faisal Maqbool
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  3. Dongying Zheng
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  4. Yongming Li
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  5. Muhammad Khan
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  6. Tonghui Ma
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Contributions

Muhammad Khan, Yongming Li and Tonghui Ma designed the study. Sameena Gul and Muhammad Faisal Maqbool searched the literature and wrote the manuscript. Dongying Zheng assisted in literature searching. Muhammad Khan analyzed and approved the manuscript.

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Correspondence to Muhammad Khan or Tonghui Ma.

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Gul, S., Maqbool, M.F., Zheng, D. et al. Alpinetin: a Dietary Flavonoid with Diverse Anticancer Effects. Appl Biochem Biotechnol 194, 4220–4243 (2022). https://doi.org/10.1007/s12010-022-03960-2

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