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Vibrio spp. and Their Vibriocin as a Vibriosis Control Measure in Aquaculture

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Abstract

Vibriosis disease is a major threat to the aquaculture industry caused by Vibrio spp. that are often resistant to antibiotics. Alternative controlling measures such as bacteriocins could be effective due to their narrow-spectrum activity. Hence, this systematic literature review (SLR) was carried out to review the feasibility of Vibrio spp. and their vibriocins to be used as a vibriosis control measure in aquaculture. A literature search using the web of science (WOS) and SCOPUS databases resulted in 42 unique articles which were reviewed. The results showed that Vibrio spp. could be used as a probiotic to control vibriosis, but not recommended due to their opportunistic nature and pathogenesis. Vibriocin showed narrow-spectrum activity against Vibrio spp. including highly pathogenic strains such as V. alginolyticus, V. harveyi, and V. parahaemolyticus. This supported this review’s hypothesis of using vibriocin as a targeted vibriosis control measure. Vibrio cholerae was the most studied and showed the highest inhibition range, inhibiting 13 different vibrio and non-vibrio species. Various innovations were reported in the field and vibriocins can now be produced on large scales using whole-cell culture. Vibriocins were structurally diverse, large molecular weight, and relatively heat stable. These vibriocins mainly inhibited the cell wall but could have other novel mechanisms. These properties could affect the extraction process as well as applications in aquaculture, hence, should be considered in future research.

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Funding

This work was supported by Talent and Publication Enhancement Research Grant (TAPE-RG) No. 55217 from University Malaysia Terengganu. We would like to thank the Centre for Research and Innovation Management (CRIM) for their assistance in gathering the resources needed in writing this review.

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Authors and Affiliations

  1. Faculty of Fisheries and Food Science, Universiti Malaysia Terengganu, Kuala Nerus, 21030, Terengganu, Malaysia

    Hassan Sheikh, Najiah Musa & Laith A. abdulrazzak

  2. Kulliyyah of Science, International Islamic University Malaysia, 25200, Kuantan, Pahang, Malaysia

    Akbar John

  3. School of Pharmaceutical Technology, Faculty of Pharmacy, University Sultan Zainal Abidin, 22200, Besut, Malaysia

    Mulham Alfatama

  4. Institute of Food Security and Sustainable Agriculture, Universiti Malaysia Kelantan, 17600, Jeli, Kelantan, Malaysia

    Anis Fadhlina

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  1. Hassan Sheikh
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Contributions

H. I.: conceptualization, methodology, and original draft writing; A. J.: methodology and original draft writing; N. M.: review and editing of final draft and funding acquisition; L. A. R.: resources; MA: review and editing of the final draft; A. F.: validation and Formal analysis.

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Correspondence to Hassan Sheikh.

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Sheikh, H., John, A., Musa, N. et al. Vibrio spp. and Their Vibriocin as a Vibriosis Control Measure in Aquaculture. Appl Biochem Biotechnol 194, 4477–4491 (2022). https://doi.org/10.1007/s12010-022-03919-3

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