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Efficient Valorization of Sugarcane Bagasse into Furfurylamine in Benign Deep Eutectic Solvent ChCl:Gly–Water

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Abstract

Recently, highly efficient production of valuable furan-based chemicals from available and renewable lignocellulosic biomass has attracted more and more attention via a chemoenzymatic route in an environmentally friendly reaction system. In this work, the feasibility of chemoenzymatically catalyzing sugarcane bagasse into furfurylamine with heterogeneous catalyst and ω-transaminase biocatalyst was developed in the deep eutectic solvent (DES) ChCl:Gly–water. Sulfonated Al-Laubanite was firstly synthesized to catalyze sugarcane bagasse to furfural. SEM, BET, XRD, and FT-IR were used to characterize Al-Laubanite. Catalyst Al-Laubanite structure was significantly different from carrier laubanite. High furfural yield (60.9%) was achieved by catalyzing sugarcane bagasse in 20 min at 170 ℃ and pH 1.0 by Al-Laubanite (2.4 wt%) in the presence of ChCl:Gly (20 wt%). Potential catalytic mechanism was proposed under the optimized catalytic condition. In addition, one recombinant E. coli CV harboring ω-transaminase could completely transform biomass-derived furfural to furfurylamine at 40 °C and pH 7.5 using L-alanine as amine donor in ChCl:Gly–water (20:80, wt:wt). This established chemoenzymatic cascade reaction strategy was successfully utilized for valorization of biomass into furan-based chemicals in the benign ChCl:Gly–water system.

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All data generated or analyzed during this study are included in this published article and its supplementary information files.

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Funding

The authors gratefully acknowledge the National Natural Science Foundation of China (No. 21978072), Natural Science Foundation of the Jiangsu Higher Education Institutions of China (No. 20KJB350003), Open Funding Project of the State Key Laboratory of Biocatalysis and Enzyme Engineering (Hubei University), and Open Project of Jiangsu Key Laboratory for Biomass-based Energy and Enzyme Technology (No. BEETKB1902).

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  1. Junhua Di, Nana Zhao and Bo Fan contributed equally to this work.

Authors and Affiliations

  1. National-Local Joint Engineering Research Center of Biomass Refining and High-Quality Utilization, Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Pharmacy, Changzhou University, Changzhou, People’s Republic of China

    Junhua Di, Nana Zhao, Bo Fan & Yu-Cai He

  2. State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-resources, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan, People’s Republic of China

    Yu-Cai He & Cuiluan Ma

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  1. Junhua Di
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Contributions

Conceptualization and methodology: J. Di. Data analysis: Nana Zhao. Software: B. Fan. Writing original manuscript: J. Di. Review and revising manuscript: Y. He. Funding acquisition: Y. He, B. Fan, C. Ma. All authors reviewed and approved the final manuscript.

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Correspondence to Yu-Cai He or Cuiluan Ma.

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Di, J., Zhao, N., Fan, B. et al. Efficient Valorization of Sugarcane Bagasse into Furfurylamine in Benign Deep Eutectic Solvent ChCl:Gly–Water. Appl Biochem Biotechnol 194, 2204–2218 (2022). https://doi.org/10.1007/s12010-021-03784-6

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