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Targeting Microbial Bio-film: an Update on MDR Gram-Negative Bio-film Producers Causing Catheter-Associated Urinary Tract Infections

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Abstract

In every age group, urinary tract infection (UTI) is found as a major recurrence infectious disorder. Bio-films produced by bacteria perform a vital role in causing infection in the tract of the urinary system, leading to recurrences and relapses. The purpose of this review is to present the role and mechanism of bio-film producing MDR Gram-negative bacteria causing UTI, their significance, additionally the challenges for remedy and prevention of catheter-associated UTI. This work appreciates a new understanding of bio-film producers which are having multi-drug resistance capability and focuses on the effect and control of bio-film producing uropathogenic bacteria related to catheterization. We have tried to analyze approaches to target bio-film and reported phytochemicals with anti-bio-film activity also updated on anti-bio-film therapy.

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Acknowledgements

The kind support of the Senior Management team, Vice-Chancellor of Centurion University Prof. Supriya Pattanayak; Dean School of Paramedics and Allied Health Sciences (SoPAHS) Prof. S.K. Jha; Head of the Department, SoPAHS, Dr. Soumya Jal is highly acknowledged.

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  1. School of Paramedics and Allied Health Sciences, Centurion University of Technology and Management, Sitapur, Odisha, India

    Susmita Chakrabarty & Monali P. Mishra

  2. School of Applied Sciences, Centurion University of Technology and Management, Sitapur, Odisha, India

    Dipankar Bhattacharyay

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  1. Susmita Chakrabarty
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Conceptualization and writing — original draft preparation: Susmita Chakrabarty (PhD scholar); supervision, helping in framing and editing — Monali Priyadarsini Mishra (supervisor) and Dipankar Bhattacharyay (co-supervisor).

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Correspondence to Monali P. Mishra.

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Chakrabarty, S., Mishra, M.P. & Bhattacharyay, D. Targeting Microbial Bio-film: an Update on MDR Gram-Negative Bio-film Producers Causing Catheter-Associated Urinary Tract Infections. Appl Biochem Biotechnol 194, 2796–2830 (2022). https://doi.org/10.1007/s12010-021-03711-9

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