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Relationship Between CASP9 and CASP10 Gene Polymorphisms and Cancer Susceptibility: Evidence from an Updated Meta-analysis

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An Author Correction to this article was published on 16 September 2021

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Abstract

Caspase-9 (CASP9) and caspase-10 (CASP10) polymorphisms were associated with human cancers; however, the results remain controversial. In this meta-analysis, we aimed to estimate the relationship among CASP9 (rs1052576, rs1052571, rs4645978, rs4645981, rs4645982, rs2308950) and CASP10 (rs13006529, rs13010627, rs3900115) polymorphisms and the overall risk of cancers. Relevant studies were obtained from Web of Science, MEDLINE, PubMed, Scopus, and Google scholar databases (updated January 1, 2021). Odds ratio (OR) and 95% confidence intervals (CIs) were measured to estimate the strength of association. Our meta-analysis included 40 studies. The rs4645981 significantly enhanced the risk of cancer under TT vs. CC (OR = 2.42), TC vs. CC (OR = 1.55), TT+ TC vs. CC (OR = 1.66), TT vs. TC + CC (OR = 1.91), and T vs. C (OR = 1.57) inheritance models. As for the rs1052571 variant, increased risk of cancer was observed under TT vs. CC (OR =1.22), TC vs. CC (OR = 1.17), and TT+ TC vs. CC (OR = 1.18) models. The stratified analysis showed a significant correlation between rs4645978 or rs4645981 polymorphisms and cancer risk, while in Asians rs4645978 conferred an increased risk of colorectal, lung, and prostate cancer. Both rs4645981 and rs1052576 polymorphisms were correlated with an enhanced risk of lung cancer. In conclusion, our meta-analysis suggested that CASP9 rs4645981 and rs1052571 polymorphisms are associated with overall cancer risk. More studies on larger populations are warranted to validate these associations.

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Authors and Affiliations

  1. Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran

    Saman Sargazi, Armin Zahedi Abghari, Shekoufeh Mirinejad & Ramin Saravani

  2. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

    Armin Zahedi Abghari & Ramin Saravani

  3. Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran

    Hosna Sarani

  4. Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

    Roghayeh Sheervalilou

  5. Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada

    Ebrahim Eskandari

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  1. Saman Sargazi
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  2. Armin Zahedi Abghari
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  5. Shekoufeh Mirinejad
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Correspondence to Saman Sargazi or Ebrahim Eskandari.

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The original online version of this article was revised: The original version of this article unfortunately contained a mistake in the captions of figures 1 and 2. The captions of figures 1 and 2 were interchanged.

Supplementary Information

ESM 1

(DOCX 17 kb)

Supplementary Table 1 Information of the studied polymorphisms

Supplementary Table 2 Main characteristics of the studies included in the meta-analysis

ESM 2

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Supplementary Fig. 1 Trial sequential analysis of 10 studies reporting CASP9 rs4645978 and rs1052576 polymorphisms. The criteria for measuring the required information size were: α = 0.05 (two-sided), β = 0.20 (power 80%), D2 = 57.0%, a relative risk increase of 10%, and an event proportion of 38.02% in the control arm. The blue cumulative Z-curve was generated by a random-effects model

Supplementary Fig. 2 Trial sequential analysis of 10 studies reporting CASP9 rs1052571 and rs4645981 polymorphisms. The criteria for measuring the required information size were α = 0.05 (two-sided), β = 0.20 (power 80%), D2 = 57.0%, a relative risk increase of 10%, and an event proportion of 38.02% in the control arm. The blue cumulative Z-curve was constructed using a random-effects model

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Sargazi, S., Abghari, A.Z., Sarani, H. et al. Relationship Between CASP9 and CASP10 Gene Polymorphisms and Cancer Susceptibility: Evidence from an Updated Meta-analysis. Appl Biochem Biotechnol 193, 4172–4196 (2021). https://doi.org/10.1007/s12010-021-03613-w

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