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Evaluation of Anticancer Activities of Novel Facile Synthesized Calix[n]arene Sulfonamide Analogs

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Abstract

Here, new calixarene sulfonamide analogs were synthesized from the reaction of chlorosulfonated calix[n]arene (n: 4, 6, and 8) with N,N′-dimethylethylenediamine or ethylenediamine for the first time and an excellent calixarene sulfonamide analog showing potent and selective cytotoxic activity on some cancer cell lines were discovered. Cytotoxicity of the prepared calix[n]arene sulfonamide analogs towards both cancer and healthy cell lines was assessed by performing cell growth inhibition assays. In cytotoxicity assay results, it was observed that while sulfonamide analog based calix[4]arene (9) was not affecting the growth of epithelial cell lines (HEK), and it was especially effective on inhibiting the growth of some human cancer cell lines (MCF-7 and MIA PaCa-2). These results highlight that sulfonamide analog–based calix [4] arene (9) can be further studied as a potential anticancer agent.

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Funding

This study is part of PhD Thesis of Bahar Yilmaz and authors received financial support from the Scientific and Technological Research Council of Turkey (TUBITAK grant no: 116Z979).

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  1. Department of Bioengineering, Karamanoglu Mehmetbey University, 70200, Karaman, Turkey

    Bahar Yilmaz, Abdullah Tahir Bayrac & Mevlut Bayrakci

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  1. Bahar Yilmaz
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  2. Abdullah Tahir Bayrac
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Correspondence to Mevlut Bayrakci.

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Yilmaz, B., Bayrac, A.T. & Bayrakci, M. Evaluation of Anticancer Activities of Novel Facile Synthesized Calix[n]arene Sulfonamide Analogs. Appl Biochem Biotechnol 190, 1484–1497 (2020). https://doi.org/10.1007/s12010-019-03184-x

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