Radiolabeling of Biogenic Magnetic Nanoparticles with Rhenium-188 as a Novel Agent for Targeted Radiotherapy
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Use of nanoparticles as carriers of anticancer drugs is a suitable way for targeted drug delivery and reduction of the side effects. This research focuses on a novel drug carrier for therapeutic goals by the bacterial magnetic nanoparticles (magnetosomes). The unique characteristics of magnetosomes make them ideal nanobiotechnological materials. In this study, magnetic nanoparticles of Alphaproteobacterium MTB-KTN90 were labeled with the radioisotope rhenium-188 and optimized the factors affecting the labeling efficiency. The results showed that the labeling efficiency of magnetosomes with rhenium-188 was more than 96%. The optimum concentration of bacterial nanoparticles was 133 mg/ml and the best time for maximum efficiency labeling was 60 min. The labeling stability showed that the 188Re-nanoparticle complexes have good stability in 29 h. The results of magnetic nanoparticles bacterial cytotoxicity on cancer cells AsPC1 did not show significant toxicity to concentration of 100 μg/μl. Finally, the biogenic magnetic nanoparticles labeled with rhenium-188 can be introduced as a valuable candidate for the targeted therapy of tumor with reducing radiation to surrounding healthy tissues.
KeywordsDrug delivery Magnetosomes Magnetotactic bacteria Nanobiotechnology Targeted therapy
This manuscript was a part of the MSc. thesis by S. Akbari-Karadeh, under the supervision of Dr. S.M.R. Aghamiri and Dr. P. Tajer-Mohammad-Ghazvini; and advisory of S. Ghorbanzadeh-Mashkani. The authors would like to thank Department of Medical Radiation Engineering, Shahid Beheshti University and also Materials and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute, Tehran, Iran for the supports through this study. The authors are grateful to Dr. Reza Dabbagh and Dr. Behrooz Alirezapour for their valuable contributions to this project.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
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