Antimicrobial Mechanism of Hydroquinone


With growing concern about the possible risks and side effects of antibiotic drugs, more and more natural products with antibacterial activity are studied as the substitutes. In this paper, the antibacterial activity of hydroquinone and arbutin in Ainsliaea bonatii was investigated, which both displayed relatively strong antibacterial activity against Staphylococcus aureus (SA), methicillin-resistant S. aureus (MRSA), and extended spectrum β-lactamase S. aureus (ESBL-SA). The antibacterial mechanism of hydroquinone had been explored by scanning electron microscopy (SEM), alkaline phosphatase (AKP), and bacterial extracellular protein leakage. Results showed that hydroquinone could destroy the bacterial cell wall and membrane, increase permeability, lead leakage of intracellular substance affect synthesis of protein, and influence expression of genes.

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We gratefully acknowledge the valuable cooperation of the members of the National Center for Research and Development of Edible Fungus Processing Technology, Henan University, in the experiments.

Funding Sources

This work was supported by grant (2017YFC1601400) from the Ministry of Science and Technology of the People’s Republic of China and grant (182102110332) from the Scientific and Technology Department of Henan Province.

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Corresponding authors

Correspondence to Jinfeng Wei or Wenyi Kang.

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We declare that the ethical background of this study was approved by the National Ethical Committee.

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Ma, C., He, N., Zhao, Y. et al. Antimicrobial Mechanism of Hydroquinone. Appl Biochem Biotechnol 189, 1291–1303 (2019).

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  • Ainsliaea bonatii
  • Hydroquinone
  • Arbutin
  • Antibacterial mechanism
  • Staphylococcus aureus