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Antimicrobial Mechanism of Hydroquinone

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Abstract

With growing concern about the possible risks and side effects of antibiotic drugs, more and more natural products with antibacterial activity are studied as the substitutes. In this paper, the antibacterial activity of hydroquinone and arbutin in Ainsliaea bonatii was investigated, which both displayed relatively strong antibacterial activity against Staphylococcus aureus (SA), methicillin-resistant S. aureus (MRSA), and extended spectrum β-lactamase S. aureus (ESBL-SA). The antibacterial mechanism of hydroquinone had been explored by scanning electron microscopy (SEM), alkaline phosphatase (AKP), and bacterial extracellular protein leakage. Results showed that hydroquinone could destroy the bacterial cell wall and membrane, increase permeability, lead leakage of intracellular substance affect synthesis of protein, and influence expression of genes.

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Acknowledgments

We gratefully acknowledge the valuable cooperation of the members of the National Center for Research and Development of Edible Fungus Processing Technology, Henan University, in the experiments.

Funding Sources

This work was supported by grant (2017YFC1601400) from the Ministry of Science and Technology of the People’s Republic of China and grant (182102110332) from the Scientific and Technology Department of Henan Province.

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Author notes

  1. Changyang Ma and Nan He contributed equally to this work.

Authors and Affiliations

  1. National R&D Center for Edible Fungus Processing Technology, Henan University, Kaifeng, 475004, Henan, China

    Changyang Ma, Jinfeng Wei & Wenyi Kang

  2. Kaifeng Key Laboratory of Functional Components in Health Food, Henan University, Kaifeng, 475004, Henan, China

    Changyang Ma, Nan He, Yingying Zhao, Dandan Xia & Wenyi Kang

  3. Joint International Research Laboratory of Food & Medicine Resource Function, Kaifeng, 475004, Henan, China

    Jinfeng Wei

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  1. Changyang Ma
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  2. Nan He
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  3. Yingying Zhao
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Correspondence to Jinfeng Wei or Wenyi Kang.

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Ma, C., He, N., Zhao, Y. et al. Antimicrobial Mechanism of Hydroquinone. Appl Biochem Biotechnol 189, 1291–1303 (2019). https://doi.org/10.1007/s12010-019-03067-1

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