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Metal Complex of the First-Generation Quinolone Antimicrobial Drug Nalidixic Acid: Structure and Its Biological Evaluation

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Abstract

A novel binuclear squire planar complex of nalidixic acid with Ag(I) metal ion with the formula [Ag(Nal)2] has been synthesized. The synthesized metal complex was characterized using CHN analysis, Fourier-transformed infra-red (FT-IR), thermo gravimetric analysis (TGA), differential scanning calorimetry (DSC), ultra violet–visible (Uv–vis) and single-crystal X-ray diffraction (XRD). The newly synthesized complex shows more advanced antifungal activity compared to the parent quinolone against four fungi, namely Pythium aphanidermatum, Sclerotinia rolfsii, Rhizoctonia solani and Rhizoctonia bataticola.

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Acknowledgments

The authors acknowledge the National Centre of Integrative Pest Management, Pusa, India for the screening of the drugs, the Department of Chemistry, University of Delhi for providing necessary facilities and the University Grant Commission (UGC) for the financial assistance.

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  1. Department of Chemistry, University of Delhi, Delhi, 110007, India

    Anamika Debnath, Navin Kumar Mogha & Dhanraj T. Masram

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  1. Anamika Debnath
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Correspondence to Dhanraj T. Masram.

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Debnath, A., Mogha, N.K. & Masram, D.T. Metal Complex of the First-Generation Quinolone Antimicrobial Drug Nalidixic Acid: Structure and Its Biological Evaluation. Appl Biochem Biotechnol 175, 2659–2667 (2015). https://doi.org/10.1007/s12010-014-1450-9

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