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Antiglycating Potential of Gum Arabic Capped-Silver Nanoparticles

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Abstract

Advanced glycation end products are major contributors to the pathology of diabetes, Alzheimer’s disease, and atherosclerosis; accordingly, identification of antiglycation compounds is attracting considerable interest. In the present study, the inhibitory effect of gum arabic capped-silver nanoparticles on advanced glycation end products formation was monitored by several biophysical techniques. Silver nanoparticles were characterized by ultraviolet–visible, high-resolution transmission electron microscopy, and energy-dispersive X-ray spectroscopy. Bovine serum albumin and methylglyoxal mixtures incubated with increasing concentrations of silver nanoparticles showed significant reductions in advanced glycation end product formation that were confirmed by ultraviolet–visible, fluorescence spectrometry, and high-performance liquid chromatography techniques. High-performance liquid chromatography showed decreased adduct formation of glycated protein in the presence of silver nanoparticles. The structural changes induced by silver nanoparticles were further confirmed by circular dichroism and Fourier transform infrared spectroscopy. Strong inhibition of advanced glycation end product formation was observed in the presence of elevated silver nanoparticles. The results of this study suggest that silver nanoparticles are a potent antiglycating agent.

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Acknowledgments

The authors thank Yeungnam University for providing financial assistance to Jalaluddin M. Ashraf. The authors also would like to acknowledge the SAIF-DST, Department of Anatomy, All India Institute of Medical Sciences (AIIMS), New Delhi, India, for HR-TEM observations, as well as the Center for Excellence in Nanomaterials, Department of Applied Physics, AMU, Aligarh, for ATR-FTIR analysis.

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Authors and Affiliations

  1. School of Biotechnology, Yeungnam University, Gyeongsan, Republic of South Korea

    Jalaluddin M. Ashraf & Inho Choi

  2. Nanotechnology and Antimicrobial Drug Resistance Research Laboratory, Department of Microbiology, Jawaharlal Nehru Medical College & Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, 202002, India

    Mohammad Azam Ansari & Haris M. Khan

  3. Department of Medical Laboratories, College of Applied Medical Science, Buraydah Colleges, Buraydah, 51452, Saudi Arabia

    Mohammad Azam Ansari & Mohammad A. Alzohairy

Authors
  1. Jalaluddin M. Ashraf
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  2. Mohammad Azam Ansari
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  3. Inho Choi
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  4. Haris M. Khan
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  5. Mohammad A. Alzohairy
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Corresponding author

Correspondence to Mohammad Azam Ansari.

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Jalaluddin M. Ashraf and Mohammad Azam Ansari are contributed equally to this work.

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Ashraf, J.M., Ansari, M.A., Choi, I. et al. Antiglycating Potential of Gum Arabic Capped-Silver Nanoparticles. Appl Biochem Biotechnol 174, 398–410 (2014). https://doi.org/10.1007/s12010-014-1065-1

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  • DOI: https://doi.org/10.1007/s12010-014-1065-1

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