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Square Planar Platinum(II) Complexes with N,S-Donor Ligands: Synthesis, Characterisation, DNA Interaction and Cytotoxic Activity

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Abstract

The platinum(II) complexes with N,S-donor ligand have been synthesised and characterised by physiological techniques like elemental, electronic, Fourier transform infrared, hydrogen-1 nuclear magnetic resonance (1H NMR) and liquid chromatography–mass spectrometry spectra. The synthesised complexes have been checked for their DNA binding ability by absorption titration and viscosity measurement, and the results show that the complexes binds to herring sperm DNA (HS DNA) via covalent mode of binding. The DNA cleavage activity of synthesised complexes has been carried out by gel electrophoresis experiment using supercoiled form of pUC19 DNA, showing the unwinding of the negatively charged supercoiled DNA. Brine shrimp (Artemia cysts) lethality bioassay technique has been applied for the determination of toxic property of synthesised complexes in terms of micromolars.

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Acknowledgements

The authors thank the Head of the Department of Chemistry, Sardar Patel University, India for making it convenient to work in laboratory and U.G.C. for providing financial support under the scheme ‘UGC Research Fellowship in Science for Meritorious Students.’

Declaration of Interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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Authors and Affiliations

  1. Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388 120, Gujarat, India

    Mohan N. Patel, Chintan R. Patel, Hardik N. Joshi & Pankaj A. Vekariya

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  1. Mohan N. Patel
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  2. Chintan R. Patel
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Correspondence to Mohan N. Patel.

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Patel, M.N., Patel, C.R., Joshi, H.N. et al. Square Planar Platinum(II) Complexes with N,S-Donor Ligands: Synthesis, Characterisation, DNA Interaction and Cytotoxic Activity. Appl Biochem Biotechnol 172, 1846–1858 (2014). https://doi.org/10.1007/s12010-013-0618-z

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