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Antioxidant and Biochemical Activities of Mixed Ligand Complexes

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Abstract

Novel 4-aminoantipyrine based mixed ligand metal complexes with the Schiff bases ofL1(L1-4(furanylmethyleneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one and L2/ L3/ L4are 2-(2-chlorobenzylideneamino)phenol, 2-(3-chlorobenzylideneamino)phenol, 2-(4-chlorobenzylideneamino)phenol were synthesized. The structures of the mixed ligand complexes were established by analytical and spectral techniques. They were screened for in vitro antimicrobial activity against bacteria and fungi by disc diffusion method. The interaction of metal complexes with CT-DNA was investigated by UV–vis, cyclic voltammetry, viscosity and thermal denaturation studies.DNA interaction studies suggest that metal complex binds to calf thymus DNA (CT-DNA) through intercalation mode. Superoxide dismutase activity of these complexes has also been studied. The free ligands and their metal complexes have been tested for in vitro antioxidant activity by the reduction of 1,1-diphenyl-2-picryl hydrazyl (DPPH).The antioxidant activities of the complexes were studied and compared with the activity of ascorbic acid. Cu(II) complex showed superior antioxidant activity than other complexes. The solvatochromic behaviour of complexes was also performed in various solvents.

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Acknowledgments

We express our sincere thanks to the Chancellor, Noorul Islam Centre for Higher Education, Kumaracoil for providing research facilities and financial support. We also express our sincere thanks to the Head, Department of Chemistry, Noorul Islam Centre for Higher Education, Kumaracoil for providing valuable research support.

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  1. Department of Chemistry, Noorul Islam Centre for Higher Education, Kumaracoil, 629180, Tamil Nadu, India

    J. Joseph & G. AyishaBibin Rani

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  1. J. Joseph
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  2. G. AyishaBibin Rani
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Correspondence to J. Joseph.

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Joseph, J., Rani, G.A. Antioxidant and Biochemical Activities of Mixed Ligand Complexes. Appl Biochem Biotechnol 172, 867–890 (2014). https://doi.org/10.1007/s12010-013-0557-8

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