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Antiviral and Antibacterial Polyurethanes of Various Modalities

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Abstract

We have prepared and characterized a new polyurethane-based antimicrobial material, N,N-dodecyl,methyl-polyurethane (Quat-12-PU). It exhibits strong antiviral and antibacterial activities when coated (as an organic solution or an aqueous nanosuspension) onto surfaces and antibacterial activity when electrospun into nanofibers. Quat-12-PU surfaces are able to kill airborne Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria, as well as inactivate the enveloped influenza virus (but not the non-enveloped poliovirus).

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Acknowledgments

This work was financially supported by a University of Colorado start-up funding (to DP), a University of Pittsburgh start-up funding (to YW), the U.S. Army Research Office through the Institute for Soldier Nanotechnology at the Massachusetts Institute of Technology (to AMK), and a Martin Family fellowship (to AML). We thank Mr. Amin Famili at the University of Colorado Denver for the DLS measurements.

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Authors and Affiliations

  1. Department of Bioengineering, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USA

    Daewon Park

  2. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

    Alyssa M. Larson & Alexander M. Klibanov

  3. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

    Alexander M. Klibanov

  4. Department of Bioengineering and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA

    Yadong Wang

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  1. Daewon Park
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  2. Alyssa M. Larson
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  3. Alexander M. Klibanov
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  4. Yadong Wang
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Correspondence to Daewon Park or Yadong Wang.

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Park, D., Larson, A.M., Klibanov, A.M. et al. Antiviral and Antibacterial Polyurethanes of Various Modalities. Appl Biochem Biotechnol 169, 1134–1146 (2013). https://doi.org/10.1007/s12010-012-9999-7

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  • DOI: https://doi.org/10.1007/s12010-012-9999-7

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