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Facilitated Transport of Penicillin G by Bulk Liquid Membrane with TBP as Carrier

Applied Biochemistry and Biotechnology volume 152, pages 286–294 (2009)Cite this article

Abstract

The facilitated transport of penicillin G from aqueous solutions to the stripping phase through bulk liquid membrane (BLM) containing TBP in 3% iso-octanol and n-butyl acetate was studied. Na2CO3 solution was used as the stripping phase. Experiments were performed as a function of stirring rate, TBP concentration and type of diluent in the liquid membrane phase, pH, and initial penicillin G concentration in the feed phase, Na2CO3 concentration in the stripping phase, etc. The results showed that the BLM process could carry out the simultaneous separation and concentration of penicillin G from dilute aqueous solutions, and arise “up-hill” effect due to the characteristic of non-equilibrium mass transfer. The diffusion of penicillin G complex in the liquid membrane phase played an important role in BLM process. The mass transfer mechanism of BLM for this system was also discussed.

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Acknowledgments

This research was supported by the National Natural Science Foundation (Grant No.20576008 and 20706003) program for New Century Excellent Talents in University (NCET-05-0122) and National Key Project of Scientific and Technical Supporting Programs funded by the Ministry of Science & Technology of the People’s Republic of China (NO. 2007BAI26D03) and research fund of The Guangdong Provincial Laboratory of Green Chemical Technology.

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  1. State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, 100029, People’s Republic of China

    Zhongqi Ren, Yuanyuan Lv & Weidong Zhang

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  1. Zhongqi Ren
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  2. Yuanyuan Lv
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  3. Weidong Zhang
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Correspondence to Weidong Zhang.

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Ren, Z., Lv, Y. & Zhang, W. Facilitated Transport of Penicillin G by Bulk Liquid Membrane with TBP as Carrier. Appl Biochem Biotechnol 152, 286–294 (2009). https://doi.org/10.1007/s12010-008-8242-z

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  • DOI: https://doi.org/10.1007/s12010-008-8242-z

Keywords

  • Bulk liquid membrane
  • Penicillin G
  • Facilitated transport
  • TBP