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Bioactive Benzopyrone Derivatives from New Recombinant Fusant of Marine Streptomyces

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Abstract

In our searching program for bioactive secondary metabolites from marine Streptomycetes, three microbial benzopyrone derivatives (1–3), 7-methylcoumarin (1) and two flavonoides, rhamnazin (2) and cirsimaritin (3), were obtained during the working up of the ethyl acetate fraction of a marine Streptomyces fusant obtained from protoplast fusion between Streptomyces strains Merv 1996 and Merv 7409. The structures of the three compounds (1–3) were established by nuclear magnetic resonance, mass, UV spectra, and by comparison with literature data. Marine Streptomyces strains were identified based on their phenotypic and chemotypic characteristics as two different bioactive strains of the genus Streptomyces. We described here the fermentation, isolation, as well as the biological activity of these bioactive compounds. The isolated compounds (1–3) are reported here as microbial products for the first time.

 

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Authors and Affiliations

  1. Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical Industries, National Research Centre, El-Behoos st. 33, Dokki-Cairo, 12622, Egypt

    Mervat M. A. El-Gendy

  2. Department of Chemistry of Natural Compounds, Division of Pharmaceutical Industries, National Research Centre, El-Behoos st. 33, Dokki-Cairo, 12622, Egypt

    M. Shaaban

  3. Applied Microbial Genetics Laboratory, Genetics and Cytology Department, National Research Centre, El-Behoos St. 33, Dokki-Cairo, 12622, Egypt

    A. M. EL-Bondkly

  4. Department of Organic Chemistry, University of Göttingen, Tammannstrasse 2, 37077, Göttingen, Germany

    K. A. Shaaban

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  1. Mervat M. A. El-Gendy
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  2. M. Shaaban
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  3. A. M. EL-Bondkly
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  4. K. A. Shaaban
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Correspondence to Mervat M. A. El-Gendy.

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El-Gendy, M.M.A., Shaaban, M., EL-Bondkly, A.M. et al. Bioactive Benzopyrone Derivatives from New Recombinant Fusant of Marine Streptomyces . Appl Biochem Biotechnol 150, 85–96 (2008). https://doi.org/10.1007/s12010-008-8192-5

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  • DOI: https://doi.org/10.1007/s12010-008-8192-5

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