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Practical Aspects of Hydrophobic Polycationic Bactericidal “Paints”

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We previously discovered that coating solid surfaces with long-chained linear N-dodecyl,N-methyl-polyethylenimine makes them bactericidal and virucidal. In the present study, focusing on the use of this microbicidal paint to kill airborne Escherichia coli and Staphylococcus aureus, we have systematically investigated the dependence of this effect on the concentration and mode of application of the hydrophobic polycation, the number of coats, the nature of the solvent, and the presence of a dye in such paint. In addition, the latter’s ability to be regenerated after use, stability upon repeated washings, and mammalian toxicity has been evaluated.

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We thank the Boeing Company for financial support of this work and Ms. Rovelyn T. Dytioco of Boeing for helpful discussions. This work was also partially supported by the US Army through the Institute for Soldier Nanotechnologies at the Massachusetts Institute of Technology under contract DAAD-19-02-D-0002 with the Army Research Office.

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Correspondence to Alexander M. Klibanov.

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Mukherjee, K., Rivera, J.J. & Klibanov, A.M. Practical Aspects of Hydrophobic Polycationic Bactericidal “Paints”. Appl Biochem Biotechnol 151, 61–70 (2008).

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