Skip to main content
SpringerLink
Log in

Analysis of Kinetic and Operational Parameters in a Structured Model for Acrylic Acid Production through Experimental Design

  • Published:
Applied Biochemistry and Biotechnology Aims and scope Submit manuscript

Abstract

In biotechnological processes, a great number of factors can influence the income productivity and conversion. Normally, it is not evident which of these factors are the most important and how they interact. In this work, multivariate analysis techniques are used as experimental design coupled to a detailed deterministic model to identify the parameters with the most significant impact on the model to represent well the acrylic acid production process. It is proposed as an alternative process, having sugarcane as feedstock, to the petrochemical-based ones that have significant environmental impacts for their production. To increase the competitiveness of renewable acrylic-acid-based process, it is necessary to find out working conditions near the optimal region, which is not an easy task, as the process is multivariable and non-linear. The mapping of the dynamics of the developed process is made using techniques of factorial design together with the methodology of Plackett–Burman. It is shown that it is possible to increase the process performance by choosing optimized conditions for the reactor operation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

Abbreviations

AA:

acrylic acid concentration

D Ai :

diffusivity

D az :

axial dispersion coefficient

D p :

particle diameter

D r :

reactor diameter

F in :

feed rate

k :

factors number

K A, K A″ :

inhibition constant related with the product

k i :

rate constant for reaction

K i :

affinity constant

K ji :

inhibition constant

L :

reactor length

p :

level of fractionation

R i :

reaction rate

S i :

extracellular concentration

S in :

feed glucose concentration

u :

superficial velocity

X in :

feed biomass concentration

X i :

active cell material

X LADH :

lactate dehydrogenase

ε :

porosity

η :

effectiveness factor

References

  1. Antony, J., & Kaye, M. (1999). In Antony, J. (2002). Training for design of experiments using a catapult. Quality and reliability engineering international, 18, 29–35.

    Google Scholar 

  2. Plackett, R. L., & Burman, J. P. (1946). The design of optimum multifactorial experiments. Biometrika, 33, 305–325.

    Article  Google Scholar 

  3. Lunelli, B. H., Duarte, E. R., Vasco de Toledo, E. C., Wolf Maciel, M. R., & Maciel Filho, R. (2007). A new process for acrylic acid synthesis by fermentative process. Applied Biochemistry and Biotechnology, 136-140, 487–500.

    Article  Google Scholar 

  4. Lei, F., Rotboll, M., & Jorgensen, S. B. (2001). A biochemically structured model for Saccharomyces cerevisiae. Journal of Biotechnology, 88, 205–221.

    Article  CAS  Google Scholar 

  5. Stremel, D. P. (2001). Desenvolvimento de modelos estruturados alternativos para o processo de produção de etanol. PhD thesis. State University of Campinas. Campinas, Brazil.

  6. Skory, C. D. (2003). Lactic acid production by Saccharomyces cerevisiae expressing a Rhizopus orizae lactate dehydrogenase gene. Journal of Industrial Microbiology & Biotechnology., 30, 22–27.

    CAS  Google Scholar 

  7. Dawes, I., & Large, P. J. (1982). Supply of carbon skeletons. In J. Mandelstam, K. McQuillen, & I. Dawes (Eds.), Biochemistry of bacterial growth. pp. 125–158. Oxford: Blackwell.

    Google Scholar 

Download references

Acknowledgements

The authors are grateful to the Fundação de Amparo à Pesquisa do Estado de São Paulo–FAPESP process number 05/53186–8 for the financial support.

Author information

Authors and Affiliations

  1. Laboratory of Optimization, Design and Advanced Control (LOPCA), Department of Chemical Process, School of Chemical Engineering, State University of Campinas (UNICAMP), PO Box 6066, Campinas, São Paulo, 13081-970, Brazil

    B. H. Lunelli, E. C. Rivera, E. C. Vasco de Toledo, M. R. Wolf Maciel & R. Maciel Filho

Authors
  1. B. H. Lunelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. C. Rivera
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. C. Vasco de Toledo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. R. Wolf Maciel
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. Maciel Filho
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to B. H. Lunelli.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lunelli, B.H., Rivera, E.C., Vasco de Toledo, E.C. et al. Analysis of Kinetic and Operational Parameters in a Structured Model for Acrylic Acid Production through Experimental Design. Appl Biochem Biotechnol 148, 175–187 (2008). https://doi.org/10.1007/s12010-007-8060-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12010-007-8060-8

Keywords

Search

Navigation