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Prospective Study Demonstrating the Efficacy of Combined Preoperative Three-Day Application of Antibiotics and Povidone–Iodine Irrigation

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Annals of Ophthalmology

Abstract

In 50 patients undergoing anterior segment intraocular surgery we determined that a three-day course of topical ofloxacin followed by preoperative povidone–iodine irrigation caused a marked decrease in the number of conjunctival bacterial flora and resulted in no contamination of the anterior chamber aqueous fluid at the beginning and conclusion of surgery.

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References

  1. Kattan HM, Flynn HW Jr, Pflugfelder SC, et al. Nosocomial endophthalmitis survey. Current incidence of infection after intraocular surgery. Ophthalmology 1991;98:227–38.

    PubMed  CAS  Google Scholar 

  2. Javitt JC, Street DA, Tielsch JM, et al. National outcomes of cataract extraction. Retinal detachment and endophthalmitis after outpatient cataract surgery. Cataract Patient Outcomes Research Team. Ophthalmology 1994;101:100–5. Discussion 106.

    PubMed  CAS  Google Scholar 

  3. Powe NR, Schein OD, Gieser SC, et al. Synthesis of the literature on visual acuity and complications following cataract extraction with intraocular lens implantation. Cataract Patient Outcome Research Team. Arch Ophthalmol 1994;112:239–52.

    PubMed  CAS  Google Scholar 

  4. Aaberg TM Jr, Flynn HW Jr, Schiffman J, et al. Nosocomial acute-onset postoperative endophthalmitis survey. A 10-year review of incidence and outcomes. Ophthalmology 1998;105:1004–10.

    Article  PubMed  Google Scholar 

  5. Ciulla TA, Starr MB, Masket S. Bacterial endophthalmitis prophylaxis for cataract surgery: an evidence-based update. Ophthalmology 2002;109:13–24.

    Article  PubMed  Google Scholar 

  6. Isenberg SJ, Apt L, Yoshimori R, et al. Chemical preparation of the eye in ophthalmic surgery. IV. Comparison of povidone–iodine on the conjunctiva with a prophylactic antibiotic. Arch Ophthalmol 1985;103:1340–42.

    PubMed  CAS  Google Scholar 

  7. Grimes SR, Mein CE, Trevino S. Preoperative antibiotic and povidone–iodine preparation of the eye. Ann Ophthalmol 1991;23:263–6.

    PubMed  CAS  Google Scholar 

  8. Ta CN, Egbert PR, Singh K, et al. Prospective randomized comparison of three-day versus 1-hour preoperative ofloxacin prophylaxis for cataract surgery. Ophthalmology 2002;109:2036–40. Discussion 2040–1.

    Article  PubMed  Google Scholar 

  9. Mino de Kaspar H, Chang RT, Singh K, et al. Prospective randomized comparison of 2 different methods of 5% povidone–iodine applications for anterior segment intraocular surgery. Arch Ophthalmol 2005;123:161–5.

    Article  PubMed  CAS  Google Scholar 

  10. Apt L, Isenberg SJ, Yoshimori R, et al. Outpatient topical use of povidone–iodine in preparing the eye for surgery. Ophthalmology 1989;96:289–92.

    PubMed  CAS  Google Scholar 

  11. Caldwell DR, Kastl PR, Cook J, et al. Povidone–iodine: its efficacy as a preoperative conjunctival and periocular preparation. Ann Ophthalmol 1984;16:577–80.

    PubMed  CAS  Google Scholar 

  12. Barry P, Seal DV, Gettinby G, et al. ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery: preliminary report of principal results from a European multicenter study. J Cataract Refract Surg 2006;32:407–10.

    Article  PubMed  Google Scholar 

  13. Beigi B, Westlake W, Chang B, et al. The effect of intracameral, per-operative antibiotics on microbial contamination of anterior chamber aspirates during phacoemulsification. Eye 1998;12:390–4.

    PubMed  Google Scholar 

  14. Tervo T, Ljungberg P, Kautiainen T, et al. Prospective evaluation of external ocular microbial growth and aqueous humor contamination during cataract surgery. J Cataract Refract Surg 1999;25:65–71.

    Article  PubMed  CAS  Google Scholar 

  15. Speaker MG, Menikoff JA. Prophylaxis of endophthalmitis with topical povidone–iodine. Ophthalmology 1991;98:1769–75.

    PubMed  CAS  Google Scholar 

  16. Speaker MG, Milch FA, Shah MK, et al. Role of external bacterial flora in the pathogenesis of acute postoperative endophthalmitis. Ophthalmology 1991;98:639–49. Discussion 650.

    PubMed  CAS  Google Scholar 

  17. Shockley RK, Jay WM, Fishman PH, et al. Effect of inoculum size on the induction of endophthalmitis in aphakic rabbit eyes. Acta Ophthalmol 1985;63:35–8.

    CAS  Google Scholar 

  18. Records RE, Iwen PC. Experimental bacterial endophthalmitis following extracapsular lens extraction. Exp Eye Res 1989;49:729–37.

    Article  PubMed  CAS  Google Scholar 

  19. Parkkari M, Paivarinta H, Salminen L. The treatment of endophthalmitis after cataract surgery: review of 26 cases. J Ocul Pharmacol Ther 1995;11:349–59.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

Authors

Corresponding author

Correspondence to Christopher N. Ta MD.

Additional information

Drs. Ta, Lin, Singh and Miño de Kaspar are from the Department of Ophthalmology, Stanford University, Stanford, CA 94304, USA. Dr. Miño de Kaspar is also from the Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.

Presented at the Association for Research in Vision and Ophthalmology Meeting, Fort Lauderdale, Florida, USA, May 2003.

The authors have stated that they do not have a significant proprietary interest in any of the products discussed in this article. Supported by the Edward E. Hills Foundation, San Francisco, California; Allergan, Inc., Irvine, California, USA and the Hannelore-Georg Zimmermann Foundation, Munich, Germany. The authors do discuss the use of off-label products, which includes unlabeled, unapproved, or investigative products or devices.

The authors demonstrated the efficacy of preoperative topical ofloxacin followed by preoperative povidone–iodine irrigation on conjunctival and anterior chamber fluid contamination rate.

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Ta, C.N., Lin, R.C., Singh, G. et al. Prospective Study Demonstrating the Efficacy of Combined Preoperative Three-Day Application of Antibiotics and Povidone–Iodine Irrigation. Ann Ophthalmol 39, 313–317 (2007). https://doi.org/10.1007/s12009-007-9007-y

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  • DOI: https://doi.org/10.1007/s12009-007-9007-y

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