Skip to main content
SpringerLink
Log in

Enhanced oxidative stress in eales disease

  • Original Article
  • Published:
Annals of Ophthalmology

Abstract

A study was undertaken to evaluate oxidative stress and oxidative defense mechanisms in 14 cases of Eales disease with retinal periphlebitis and 10 controls. Alterations in activity of the enzymes sueeroxide dismutase and catalase in platelets and the lipid peroxidation product malondialdehyde were estimated biochemically. Enhanced oxidative stress (significantly increased malondialdehyde levels and decreased superoxide dismutase enzyme activity) was detected. Results suggest involvement of free radicals in the pathogenesis of Eales disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Geiser SC, Murphy RP. Eales disease. In: Ryan SJ, ed. Retina. Vol 2. Medical Retina. St Louis, Mo: CV Mosby; 1994:1903–1507.

    Google Scholar 

  2. Kumar D, Saxena RC, Saxena S. Vitreous haemorrhage in Eales disease. Afro-Asian J Ophthalmol. 1995;13:109–112.

    Google Scholar 

  3. Saxena S, Kumar D, Singh VK, Rajasingh J. Immunological studies in Eales disease: a review. Afro-Asian J Ophthalmol. 1995;13:19–22.

    Google Scholar 

  4. Rao NA, Du GS, Pararajasekaram G. Mechanism of tissue injury in uveitis. Reg Immunol. 1994;182:95–100.

    Google Scholar 

  5. Bhooma V, Sulochana KH, Biswas J, Ramakrishnan S. Eales disease: accumulation of reactive oxygen intermediates and lipid peroxides and decrease of antioxidants causing inflammation, neovascularization and retinal damage. Curr Eye Res. 1997;16:91–95.

    Article  PubMed  CAS  Google Scholar 

  6. Brokeman MJ. Stimulated platelet release equivalent amounts of arachidonate from phosphatidylcholine phosphatidyl ethanolamine and inositides. J Lipid Res. 1986;27:884–891.

    Google Scholar 

  7. Bohme DH, Kosecki R, Carson S, Stern F, Marks N. Lipid peroxidation in human and rat brain tissue: developmental and regional studies. Brain Res. 1977;136:11–21.

    Article  Google Scholar 

  8. Nishikimi M, Rao NA, Kunto Y. The occurrence of superoxide anion in reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun. 1972;46:849–853.

    Article  PubMed  CAS  Google Scholar 

  9. Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121–126.

    Article  PubMed  CAS  Google Scholar 

  10. Handelman GJ, Dratz EA. The role of antioxidants in the retina and retinal pigment epithelium and the nature of peroxide induced damage. Adv Free Radicals Biol Med. 1986:1–89.

  11. Verma SD, Lerman S. Proceedings of the first international symposium on light and oxygen effects on the eye. Curr Eye Res. 1984; 3:1–271.

    Google Scholar 

  12. Amstrong D, Hartnett M, Browne R, et al. Lipid peroxide induced synthesis of cytokine growth factors during neovascularization in the retina [abstract]. Invest Ophthalmol Vis Sci. 1995;36(suppl 4):455.

    Google Scholar 

  13. Rao NA, Sevanian A, Fernandez MA, et al. Role of oxygen radicals in experimental allergic uveitis. Invest Ophthalmol Vis Sci. 1987; 28:886–892.

    PubMed  CAS  Google Scholar 

  14. Wu GS, Goto H, Sevanian A, Rao NA. Generation of chemiluminescence in experimental autoimmune uveitis. Curr Eye Res. 1991;10:909–917.

    PubMed  CAS  Google Scholar 

  15. Goto H, Yamakawa N, Hasemi M, Matsuura G, Usui M. Superoxide generated by polymorphonuclear leucocytes and retinal lipid peroxidation in uveoretinitis. Nippon Ganka Gakkai Zasshi. 1994; 98:1019–1026.

    PubMed  CAS  Google Scholar 

  16. Hu S, Li S, Pan S, Xie C, Huang X, Mao W. Effects of superoxide dismutase on experimental allergic uveitis. Yen Ko Hsuch Pao. 1993;2:103–105.

    Google Scholar 

  17. Rao NA, Romero JL, Fernandez MA, Sevanian A, Marak GE Jr. Role of free radicals in uveitis. Surv Ophthalmol. 1987;32:209–213.

    Article  PubMed  CAS  Google Scholar 

  18. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG Carotenoids in human macular and whole retina. Invest Ophthalmol Vis Sci. 1988; 29:850–855.

    PubMed  CAS  Google Scholar 

  19. Krinsky NI. Antioxidant functions of carotenoids. Free Radicals Biol Med. 1989;7:617–635.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, King George's Medical College, University of Lucknow, G-19 River Bank Colony, 226018, Lucknow, India

    Sandeep Saxena MS,  Dipak Kumar MS &  Prachi Srivastava MSc

  2. Developmental Toxicology Division, Industrial Toxicology Research Centre, 226 001, Lucknow, India

    Vinay K. Khanna PhD &  P. K. Seth PhD

Authors
  1. Sandeep Saxena MS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vinay K. Khanna PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dipak Kumar MS
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Prachi Srivastava MSc
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. K. Seth PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Saxena, S., Khanna, V.K., Kumar, D. et al. Enhanced oxidative stress in eales disease. Ann Ophthalmol 33, 40–42 (2001). https://doi.org/10.1007/s12009-001-0071-4

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12009-001-0071-4

Keywords

Search

Navigation