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Antineovascular effect of α-interferon on corneal neovascularization in rats

  • Original Article
  • Published:
Annals of Ophthalmology

Abstract

Clinical and histologic effects of topical recombinant α-interferon (IFN), systemic IFN, topical dexamethasone, and dexamethasone plus topical IFN on corneal neovascularization in response to silver nitrate cauterization were investigated in 110 eyes of 60 Wistar rats. The eyes were evaluated according to the burn stimulus, neovascularization, and histologic inflammation grades 5 days after cauterization. Antineovascular effects of topical and systemic IFN were significantly greater than a placebo but less than dexamethasone alone or in combination with IFN.

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Authors and Affiliations

  1. Department of Ophthalmology, Celal Bayar University, Manisa, Turkey

    Faruk Öztürk MD &  S. Sami Ilker MD

  2. Department of Ophthalmology, Gülhane Military Medical Academy, Ankara, Turkey

    Güngör Sobaci MD

  3. Department of Pathology, Gülhane Military Medical Academy, Ankara, Turkey

    Cevat Can MD

Authors
  1. Faruk Öztürk MD
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  2. Güngör Sobaci MD
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  3. S. Sami Ilker MD
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  4. Cevat Can MD
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Öztürk, F., Sobaci, G., Sami Ilker, S. et al. Antineovascular effect of α-interferon on corneal neovascularization in rats. Ann Ophthalmol 33, 35–39 (2001). https://doi.org/10.1007/s12009-001-0070-5

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  • DOI: https://doi.org/10.1007/s12009-001-0070-5

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