Skip to main content
SpringerLink
Log in

Simultaneous cytomegalovirus retinitis and central retinal vein occlusion of a heart transplant recipient

  • Case Report
  • Published:
Annals of Ophthalmology

Abstract

Cytomegalovirus (CMV) retinitis after heart transplantation is well documented, but few cases of central retinal vein occulusion (CRVO) have been described in these patients. A man seropositive to CMV antigen after heart transplantation received prophylactic ganciclovir therapy. Nevertheless, cytomegalovirus retinitis developed and CRVO was diagnosed in his other eye. Common risk factors for retinalvein occlusion were excluded., Cytomegalovirus infection may have played a role in the pathogenesis of CRVO.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Porter R, Crombie AL, Gardner PS, Udall RP. Incidence of ocular complications in patients undergoing renal transplantation. Br Med J. 1972;3:133–166.

    Article  PubMed  CAS  Google Scholar 

  2. Rubin RH, Cosimi B, Tolkoff-Rubin NE et al. Infectious disease syndromes attributable to cytomegalovirus and their significance among renal transplant recipients. Transplantation. 1997;24:458–464.

    Article  Google Scholar 

  3. Pollard RB. Cytomegalovirus infections in renal, heart, heart-lung and liver transplantation. Pediatr Infect Dis J. 1988;7:S97-S102.

    Article  PubMed  CAS  Google Scholar 

  4. Cortina P, Díaz M, Espana E, et al. Acute frosted retinal periphlebitis associated with cytomegalovirus retinitis in a heart transplant patient. Retina. 1994;14:463–464.

    Article  PubMed  CAS  Google Scholar 

  5. Erice A, Jordan MC, Chace BA, et al. Ganciclovir treatment of cytomegalovirus disease in transplant recipients and other immunocompromised hosts. JAMA. 1987;257:3082–3087.

    Article  PubMed  CAS  Google Scholar 

  6. Keller JC, Linn JE. Central retinal vein occlusion, in a heart trasplant patient: a case report. J Tenn Med Assoc. 1990;83:347.

    PubMed  CAS  Google Scholar 

  7. Quinlan MF, Salmon JF. Ophthalmic complications after heart transplantation. J Heart Lung Transplant. 1993;12:252–255.

    PubMed  CAS  Google Scholar 

  8. Klaver CCW, Hoyng CB, de Jong PTVM. Pigmentary irregularities and optic disc edema after heart transplantation. Arch Ophthalmol. 1995;113:1281–1285.

    PubMed  CAS  Google Scholar 

  9. Chou S. Acquisition of donor strains of cytomegalovirus by renal transplant recipients. N Engl J Med. 1986;314:1418–1423.

    Article  PubMed  CAS  Google Scholar 

  10. Schooley RT, Hirsch MS, Colvin RB, et al Association of herpesvirus infections with T-lymphocyte-subset alterations, glomerulopathy, and opportunistic infections after renal transplantation. N Engl J Med. 1983;308:307–313.

    Article  PubMed  CAS  Google Scholar 

  11. Rasmussen L, Kelsall D, Nelson R, et al Virus-specific IgG and IgM antibodies in normal and immunocompromised subjects infected with cytomegalovirus. J Infect Dis. 1982;145:191–199.

    PubMed  CAS  Google Scholar 

  12. Gutman FA. Evaluation of a patient with central retinal vein occlusion., Ophthalmology. 1983;90:481–483.

    PubMed  CAS  Google Scholar 

  13. Allison RW, Limstrom SA, Sethi GK, Copeland JG. Central retinal vein occlusion after heart-lung transplantation. Ann Ophthalmol. 1993;25:58–63.

    Google Scholar 

  14. Solis RT, Kennedy PS, Beall AC, Jr, et al. Cardiopulmonary bypass: microembolization and platelet aggregation. Circulation. 1975;52: 103–108.

    PubMed  CAS  Google Scholar 

  15. Bartosh SM, Aronson AJ, Swanson-Pewitt EE, Thistlethwaite JR Jr. OKT3 induction in pediatric renal transplantation. Pediatr Nephrol. 1993;7:45–49.

    Article  PubMed  CAS  Google Scholar 

  16. Myers BD, Newton L, Boshkos C, et al. Chronic injury of human renal microvessels with low-dose cyclosporine therapy. Transplantation. 1988;46:694–703.

    Article  PubMed  CAS  Google Scholar 

  17. Ho DD, Rota TR, Andrews CA, Hirsch MS. Replication of human cytomegalovirus in endothelial cells. J Infect Dis. 1984;150:956–957.

    PubMed  CAS  Google Scholar 

  18. Bruggeman CA, Debie WHM, Muller AD, et al. Cytomegalovirus alters the von Willebrand factor content in human endothelial cells. Thromb Haemost.. 1988;59:264–268.

    PubMed  CAS  Google Scholar 

  19. Hendrix MGR, Salimans MMM, van Boven CPA, Bruggeman CA. High prevalence of latently present cytomegalovirus in arterial walls of patients suffering from grade III atherosclerosis. Am J Pathol. 1990;136:23–28.

    PubMed  CAS  Google Scholar 

  20. Arav-Boger R, Reif S, Bujanover Y. Portal vein thrombosis caused by protein C and protein S deficiency associated with cytomegalovirus infection. J Pediatr. 1995;126:586–588.

    Article  PubMed  CAS  Google Scholar 

  21. Muldoon J, O'Riordan K, Rao S, Abecassis M. Ischemic colitis secondary to venous thrombosis: a rare presentation of cytomegalovirus vasculitis following renal transplantation. Transplantation. 1996;61:1651–1653.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology., University Hospital “La Fe”, c/Stma. Trinidad, 24 Bajo, 46290, Alcacer, Valencia, Spain

    Juan A. Aviñó MD,  Enrique España MD, PhD,  Manuel Díaz-Llopis MD, PhD &  José L. Menezo MD, PhD

  2. Department of Optics, University of Valencia, Valencia, Spain

    Enrique España MD, PhD

  3. Department of Cardiology, University Hospital “La Fe”, Spain

    Luis Almenar MD

  4. Department of Internal Medicine, University Hospital “La Fe”, Spain

    Marino Blanes MD

  5. University of the Basque Country, Basque Country, Spain

    Manuel Díaz-Llopis MD, PhD

  6. Department of Surgery, University of Valencia, Valencia, Spain

    José L. Menezo MD, PhD

Authors
  1. Juan A. Aviñó MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Enrique España MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Luis Almenar MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Marino Blanes MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Manuel Díaz-Llopis MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. José L. Menezo MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aviñó, J.A., España, E., Almenar, L. et al. Simultaneous cytomegalovirus retinitis and central retinal vein occlusion of a heart transplant recipient. Ann Ophthalmol 33, 60–63 (2001). https://doi.org/10.1007/s12009-001-0058-1

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12009-001-0058-1

Keywords

Search

Navigation