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Topical 0.3% ciprofloxacin vs topical 0.3% ofloxacin in early treatment of Pseudomonas aeruginosa keratitis in a rabbit model

  • Original Article
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Annals of Ophthalmology

Abstract

An in vivo prospective study compared the effectiveness of 0.3% ciprofloxacin to 0.3% ofloxacin against Pseudomonas aeruginosa keratitis in rabbits. Ofloxacin-treated corneas yielded an average amount of colony-forming units (CFUs) of P aeruginosa that was statistically significantly higher than that of ciprofloxacin-treated corneas (4.7×104±2.2×103 vs 2.5×103±1.0×102). Thus, ciprofloxacin was more effective than ofloxacin in the early reduction of CFUs in P aeruginosa keratitis in rabbits.

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Authors and Affiliations

  1. Krieger Eye Institute, Sinai Hospital, 2411 West Belvedere Ave., 21215, Baltimore, MD

    Scott E. LaBorwit MD,  Harold R. Katz MD,  Marc J. Hirschbein MD,  Michael R. Oswald MD,  Lori S. Snyder MD,  Ken S. Schwartz MD &  Irvin E. Herling DVM

  2. Wilmer Eye Institute, Baltimore, MD

    Scott E. LaBorwit MD &  Harold R. Katz MD

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  1. Scott E. LaBorwit MD
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  2. Harold R. Katz MD
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  3. Marc J. Hirschbein MD
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  7. Irvin E. Herling DVM
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LaBorwit, S.E., Katz, H.R., Hirschbein, M.J. et al. Topical 0.3% ciprofloxacin vs topical 0.3% ofloxacin in early treatment of Pseudomonas aeruginosa keratitis in a rabbit model. Ann Ophthalmol 33, 48–52 (2001). https://doi.org/10.1007/s12009-001-0055-4

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  • DOI: https://doi.org/10.1007/s12009-001-0055-4

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