Skip to main content
Log in

Indocyanine green angiography-guided laser photocoagulation for occult choroidal neovascularization in age-related macular degeneration

  • Original Article
  • Published:
Annals of Ophthalmology

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

Resolution of exudative manife stations and changes in vision were compared in patients who had indocyanine green angiography-guided laser photocoagulation versus those who had no laser. A retrospective, nonrandomized study was conducted in 176 patients who had laser photocoagulation therapy for occult choroidal neovascularization in age-related macular degeneration. Forty-three percent of 93 treated patients had complete resolution of exudative manifestations and 29% obtained better vision, versus 13% and 11%, respectively, for patients without laser treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Bressler SB, Bressler NM, Fine SL, et al. Natural course of choroidal neovascular membranes within the foveal avascular zone in senile macular degeneration. Am J Ophthalmol. 1982;93:157–163.

    PubMed  CAS  Google Scholar 

  2. Guyer DR, Fine SL, Maguire MG, Hawkins BS, Owens SL, Murphy RP. Subfoveal choroidal neovascular membranes in age-related macular degeneration: visual prognosis in eyes with relatively good initial visual acuity. Arch Ophthalmol. 1986;104:702–705.

    PubMed  CAS  Google Scholar 

  3. Archer, D, Krill AF, Newell FW. Fluorescein studies of normal choroidal circulation. Am J Ophthalmol. 1970;69:543–554.

    PubMed  CAS  Google Scholar 

  4. Schatz HS, Burton T, Yannuzzi LA, Rabb MF. Interpretation of Fundus Fluorescein Angiography. St. Louis, Mo. CV Mosby; 1978.

    Google Scholar 

  5. Macular Photocoagulation Study Group. Subfoveal neovascular lesions in AMD: guidelines for evaluation and treatment. Arch Ophthalmol. 1991;109:1242–1258.

    Google Scholar 

  6. Macular Photocoagulation Study Group. Argon laser photocoagulation for age-related macular degeneration. Arch Ophthalmol. 1982;100:912–918.

    Google Scholar 

  7. Macular Photocoagulation Study Group. Krypton laser photocoagulation for neovascular lesions of age-related macular degeneration. Arch Ophthalmol. 1990;108:816–824.

    Google Scholar 

  8. Macular Photocoagulation Study Group. Argon laser photocoagulation of neovascular maculopathy. Arch Ophthalmol. 1991;109:1109–1114.

    Google Scholar 

  9. Macular Photocoagulation Study Group. Recurrent choroidal neovascularization after argon laser for neovascular maculopathy. Arch Ophthalmol. 1986;104:503–512.

    Google Scholar 

  10. Laser photocoagulation of subfoveal neovascular lesions in age-related macular degeneration: results of a randomized clinical trial [editorial]. Arch Ophthalmol. 1991;109:1220–1231.

  11. Kogure K, Choromokes E. Infrared absorption angiography. J Appl Physiol. 1969;26:154–157.

    PubMed  CAS  Google Scholar 

  12. Kogure K, David NJ, Yamanouchi U, Choromokos E. Infrared absorption angiography of the fundus circulation. Arch Ophthalmol. 1970;83:209–214.

    PubMed  CAS  Google Scholar 

  13. David NJ. Infrared Absorption Fundus Angiography. In: Proceedings of the International Symposium on Fluorescein Angiography, Albi 1969. Basel, Switzerland: Karger; 1971:189–192.

    Google Scholar 

  14. Cherrick, GR, Stein SW, Leey CM, et al. Indocyanine green: observations on its physical properties, plasma decay and hepatic extraction. J Clin Invest. 1960;39:592–600.

    Article  PubMed  CAS  Google Scholar 

  15. Baker KJ. Binding of sulfobromophthalein (BSP) sodium and indocyanine green (ICC) by plasma A1-lipoproteins. Proc Soc Exp Biol Med. 1966;122:957–963.

    PubMed  CAS  Google Scholar 

  16. Fox IS, Wood EH, Indocyanine green: physical and pathological properties. Proc Mayo Clin. 1960;35:732.

    PubMed  CAS  Google Scholar 

  17. Flower RW, Hochheimer BF. Clinical infrared absorption angiography of the choroid [letter]. Am J Ophthalmol. 1972;73:458–459.

    PubMed  CAS  Google Scholar 

  18. Flower RW. Infrared absorption angiography of the choroid and some observations on the effects of high intraocular pressures. Am J Ophthalmol. 1972;74:600–614.

    PubMed  CAS  Google Scholar 

  19. Flower RW, Hochheimer BF. Indocyanine green dye fluorescence and infrared absorption choroidal angiography performed simultaneously with fluorescein angiography. Johns Hopkins Med J. 1976;138:3–42.

    Google Scholar 

  20. Benson RC, Kues HA. Fluorescence properties of indocyanine green as related to angiography. Phys Med Biol. 1978;23:159–163.

    Article  PubMed  CAS  Google Scholar 

  21. Hyarinen L, Flower RW. Indocyanine green fluorescent angiography. Arch Ophthalmol. 1980;58:528–538.

    Google Scholar 

  22. Hope-Ross M, Yannuzzi LA, Gragoudas ES, et al. Adverse reactions due to indocyanine green. Ophthalmology. 1994;101:529–532.

    PubMed  CAS  Google Scholar 

  23. Cashi TR, Steller BJ, Hepner C. Adverse reactions after administration of indocyanine green. JAMA. 1978;240:635.

    Article  Google Scholar 

  24. Yannuzzi LA, Rohrer KT, Tindel LJ. Fluorescein angiography complication survey. Ophthalmology. 1986;93:611–617.

    PubMed  CAS  Google Scholar 

  25. Iseki K, Onoyana K, Fujioni S. Shock caused by indocyanine green dye in chronic hemodialysis patients [letter]. Clin Nephrol. 1986;14:210.

    Google Scholar 

  26. Patz A, Flower RW, Klein ML, et al. Clinical applications of indocyanine green angiography. Coc Ophthalmol Proc Ser. 1976;9:245–251.

    Google Scholar 

  27. Bischoff PM, Flower RW. Ten years experience with choroidal angiography using indocyanine green dye: a new routine examination or an epilogue? Doc Ophthalmol. 1985;60:235–291.

    Article  PubMed  CAS  Google Scholar 

  28. Hayashi K, DeLaey JJ. Indocyanine green angiography of neovascular membranes. Ophthalmologica. 1985;190:30–39.

    Article  PubMed  CAS  Google Scholar 

  29. Hayashi K, Hasegawa Y, Tokoro T, Delaey JJ. Value of indocyanine green angiography in the diagnosis of occult choroidal neovascular membrane. Jpn J Ophthalmol. 1988;42:827–829.

    Google Scholar 

  30. Hayashi K, Hasegawa Y, Tazawa Y, Delaney JJ. Clinical application of indocyanine green angiography to choroid neovascularization. Jpn J Ophthalmol. 1989;33:57–68.

    PubMed  CAS  Google Scholar 

  31. Destro M, Puliafito CA. Indocyanine green videoangiography of choroidal neovascularization. Ophthalmology. 1989;96:846–853.

    PubMed  CAS  Google Scholar 

  32. Gyer DR, Puliafito CA, Mones JA, et al. Digital indocyanine green angiography in chorioretinal disorders. Ophthalmology. 1992;99:287–290.

    Google Scholar 

  33. Yannuzzi LA, Slakter JS, Sorenson JA, Guyer DR, Orlock DA. Digital indocyanine green videoangiography and choroidal neovascularization. Retina. 1992;12:191–221.

    Article  PubMed  CAS  Google Scholar 

  34. Yuzawa M, Kawamura A, Matsui M. Clinical evaluation of indocyanine green videoangiography in the diagnosis of choroidal neovascular membrane associated with age-related macular degeneration. Eur J Ophthalmol. 1992;2:115–21.

    PubMed  CAS  Google Scholar 

  35. Scheider A, Schroedel C. High resolution indocyanine green angiography with scanning laser ophthalmoscope. Am J Ophthalmol. 1989;108:458–459.

    PubMed  CAS  Google Scholar 

  36. Slakter JS, Yamuzzi LA, Sorenson JA, Guyer DR, Ho AC, Orlock DA. Aplot study of indocyanine green videoangiography-guided laser photocoagulation of occult choroidal neovascularization in age-related macular degeneration. Arch Ophthalmol. 1994;112:465–472.

    PubMed  CAS  Google Scholar 

  37. Guyer DR, Yannuzzi LA, Slakter JS, Sorenson JA, Hope-Ross M, Orlock DR. Digital indocyanine green videoangiography of occult choroidal neovascularization. Ophthalmology. 1994;101:1727–1737.

    PubMed  CAS  Google Scholar 

  38. Guyer DR, Yannuzzi LA, Slakter JS, Sorenson JA, Orlock D. The status of indocyanine green videoangiography. Retina Vitreous Disord. 1993:3-G.

  39. Reichel E, Duker JS, Puliafito CA. Indocyanine green angiography and choroidal neovascularization obscured by hemorrhage. Ophthalmology. 1995;102:12:1871–1876.

    PubMed  CAS  Google Scholar 

  40. Lim JI, Sternberg P, Capone A, Aaberg TM, Gilman JR. Selective use of indocyanine green angiography for occult choroidal neovascularization. Am J Ophthalmol. 1995;120:75–82.

    PubMed  CAS  Google Scholar 

  41. Lim JI, Aaberg TM, Capone A, Sternberg P. Indocyanine green angiography-guided photocoagulation of choroidal neovascularization associated with retinal pigment epithelial detachment. Am J Ophthalmol. 1997;123:524–532.

    PubMed  CAS  Google Scholar 

  42. Bressler NM, Bressler SB. Indocyanine green angiography[editorial]. Arch Ophthalmol. 1996;114:747–749.

    PubMed  CAS  Google Scholar 

  43. Bressler NM, Frost LA, Bressler SB, et al. Natural course of poorly defined choroidal neovascularization associated with macular degeneration. Arch Ophthalmol. 1988;166:1537–1542.

    Google Scholar 

  44. Soubrane G, Coscas G, Francois C, Francois K. Occult sub-retinal new vessels in age-related macular degeneration: natural history and early laser treatment. Ophthalmology. 1990;97:649–657.

    PubMed  CAS  Google Scholar 

  45. Macular Photocoagulation Study Group. Occult choroidal neovascularization: influence on visual outcome in patients with age-related macular degeneration. Arch Ophthalmol. 1996;44:400–412.

    Google Scholar 

  46. Chang TS, Freund KB, de la Cruz Z, Yannuzzi LA, Green WR. Clinicopathologic correlation of choroidal neovascularization demonstrated by ICG angiography in a patient with retention of good vision for almost four years. Retina. 1994;14:114–124.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Milewski, S.A., Stoj, M.J., Neuwirth, J. et al. Indocyanine green angiography-guided laser photocoagulation for occult choroidal neovascularization in age-related macular degeneration. Ann Ophthalmol 33, 225–230 (2001). https://doi.org/10.1007/s12009-001-0032-y

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12009-001-0032-y

Keywords

Navigation