A case-control masked study was performed in 37 patients with chronic fatigue syndrome (GFS) to evaluate ocular signs, symptoms, and functional parameters. A significant association was found between CFS and blurred vision at near, foggy vision, shadowed vision, headaches, and photophobia. Blurred vision, foggy vision, and headaches were associated with abnormal oculomotor function, and shadowed vision and photophobia were associated with tear deficiency. These data suggest that CFS affects the ocular system.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Holmes GP, Kaplan JE, Gantz NM. Chronic fatigue syndrome: a working case definition. Ann Intern Med. 1988;108:387–389.
Fukuda K, Straus SE, Hickie I, and the International Chronic Fatigue Syndrome Study Group: The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med. 1994;121:953–959.
Kroenke K, Wood DR, Mangelsdorff AD. Chronic fatigue in primary care: prevalence, patient characteristics, and outcome. JAMA. 1988;260:929–934.
Behan PO, Behan WMH, Bell EJ. The postviral fatigue syndrome: an analysis of the findings in 50 cases. J Infect Dis. 1985;10:211–222.
Swartz MN. The chronic fatigue syndrome—one entity or many? N Engl J Med. 1988;319:1726–1728.
Gantz NM, Holmes GP. Treatment of patients with chronic fatigue syndrome. Drugs. 1989;38:855–862.
Komaroff AL, Goldberg D. The chronic fatigue syndrome: definition, current status, and lessons for fibromyalgia research. J Rheumatol. 1989;19:23–27.
Straus SE, Dale JK, Wright R. Allergy and the chronic fatigue syndrome. J Allergy Clin Immunol. 1988;81:791–795.
Caffery BE. The ocular signs and symptoms of chronic fatigue syndrome. In: Proceedings of the American Academy of Optometry Annual Meeting; December 1990; Nashville, Tenn; 21–24.
Caffery BE, Josephson JE, Samek MJ. The ocular signs and symptoms of chronic fatigue syndrome. J Am Optom Assoc. 1994;65:187–191.
Karnezis TA, Murphy MB, Weber RR. Effects of selective dopamine-1-receptor activation on intraocular pressure in man. Exp Eye Res. 1988;47:689–698.
Wong R, Lopaschuk G, Zhu G. Skeletal muscle metabolism in the chronic fatigue syndrome. Chest. 1992;101:1716–1722.
Behan WNM, More IAR, Behan PO. Mitochondrial abnormalities in the postviral fatigue syndrome. Acta Neuropathol. 1991;83:61–65.
Pizzigallo E, Di Girolamo A, Montanari G. Alterations in muscles of CFS patients at morphological, biochemical, and molecular levels. In: Proceedings of the First World Congress on Chronic Fatigue Syndrome and Related Disorders; Brussels, Belgium; November 9–11, 1995; 17.
Holmes GP, Kaplan JE, Steward SA. A cluster of patients with a chronic mononucleosis-like syndrome: is Epstein-Barr virus the cause? JAMA. 1987;257:2297–2302.
Strauss SE, Dale JK, Peter JB. Circulating lymphokines in the chronic fatigue syndrome. J Infect Dis. 1989;160:1085–1086.
Caligiuri M, Murray C, Buchwald D. Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome. J Immunol. 1987;138:3306–3313.
Potaznick W, Kozol N. Ocular manifestation of chronic fatigue syndrome and immune dysfunction syndrome. Opt Vis Sci. 1992;69:811–814.
Rights and permissions
About this article
Cite this article
Mastropasqua, L., Ciancaglini, M., Carpineto, P. et al. Ocular manifestations in chronic fatigue syndrome. Ann Ophthalmol 32, 219–224 (2000). https://doi.org/10.1007/s12009-000-0059-5
- Chronic Fatigue Syndrome
- Pupil Diameter
- Ocular Symptom
- Chronic Fatigue Syndrome Patient
- Ocular Manifestation