Skip to main content

New Definition for Periprosthetic Joint Infection: From the Workgroup of the Musculoskeletal Infection Society

This is a preview of subscription content, access via your institution.

References

  1. Bedair H, Ting N, Jacovides C, Saxena A, Moric M, Parvizi J, Della Valle CJ. The Mark Coventry Award. Diagnosis of early postoperative TKA infection using synovial fluid analysis. Clin Orthop Relat Res. 2011;469:34–40.

    PubMed  Article  Google Scholar 

  2. Berbari E, Mabry T, Tsaras G, Spangehl M, Erwin PJ, Murad MH, Steckelberg J, Osmon D. Inflammatory blood laboratory levels as markers of prosthetic joint infection: a systematic review and meta-analysis. J Bone Joint Surg Am. 2010;92:2102–2109.

    PubMed  Article  Google Scholar 

  3. Bilgen O, Atici T, Durak K, Karaeminoğullari, Bilgen MS. C-reactive protein values and erythrocyte sedimentation rates after total hip and total knee arthroplasty. J Int Med Res. 2001;29:7–12.

    PubMed  CAS  Google Scholar 

  4. Deirmengian C, Hallab N, Tarabishy A, Della Valle C, Jacobs JJ, Lonner J, Booth RE. Synovial fluid biomarkers for periprosthetic infection. Clin Orthop Relat Res. 2010;468:2017–2023.

    PubMed  Article  Google Scholar 

  5. Della Valle CJ, Sporer SM, Jacobs JJ, Berger RA, Rosenberg AG, Paprosky WG. Preoperative testing for sepsis before revision total knee arthroplasty. J Arthroplasty. 2007;22(6 Suppl 2):90–93.

    PubMed  Article  Google Scholar 

  6. Di Cesare PE, Chang E, Preston CF, Liu CJ. Serum interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplasty. J Bone Joint Surg Am. 2005;87:1921–1927.

    PubMed  Article  Google Scholar 

  7. Ghanem E, Ketonis C, Restrepo C, Joshi A, Barrack R, Parvizi J. Periprosthetic infection: where do we stand with regard to Gram stain? Acta Orthop. 2009;80:37–40.

    PubMed  Article  Google Scholar 

  8. Ghanem E, Parvizi J, Burnett RS, Sharkey PF, Keshavarzi N, Aggarwal A, Barrack RL. Cell count and differential of aspirated fluid in the diagnosis of infection at the site of total knee arthroplasty. J Bone Joint Surg Am. 2008;90:1637–1643.

    PubMed  Article  Google Scholar 

  9. Larsson S, Thelander U, Friberg S. C-reactive protein (CRP) levels after elective orthopedic surgery. Clin Orthop Relat Res. 1992;275:237–242.

    PubMed  Google Scholar 

  10. Mariani BD, Martin DS, Levine MJ, Booth RE Jr, Tuan RS. The Coventry Award. Polymerase chain reaction detection of bacterial infection in total knee arthroplasty. Clin Orthop Relat Res. 1996;331:11–22.

    PubMed  Article  Google Scholar 

  11. Parvizi J, Ghanem E, Menashe S, Barrack RL, Bauer TW. Periprosthetic infection: what are the diagnostic challenges? J Bone Joint Surg Am. 2006;88(Suppl 4):138–147.

    PubMed  Article  Google Scholar 

  12. Parvizi J, Jacovides C, Adeli B, Jung KA, Hozack WJ. Mark B. Coventry Award. Synovial C-reactive protein: A prospective evaluation of a molecular marker for periprosthetic knee joint infection. Clin Orthop Relat Res. 2011 July 23 [Epub ahead of print].

  13. Parvizi J, Jacovides C, Antoci V Jr, Ghanem E. Diagnosis of periprosthetic joint infection: The role of a simple, yet unrecognized enzyme. J Bone Joint Surg Am. 2011;90(24).

  14. Parvizi J, Jacovides C, Zmistowski B, Jung KA. Definition of periprosthetic joint infection: Is there a consensus? Clin Orthop Relat Res. 2011 July 13 [Epub ahead of print].

  15. Schinsky MF, Della Valle CJ, Sporer SM, Paprosky WG. Perioperative testing for joint infection in patients undergoing revision total hip arthroplasty. J Bone Joint Surg Am. 2008;90:1869–1875.

    PubMed  Article  Google Scholar 

  16. Trampuz A, Hanssen AD, Osmon DR, Mandrekar J, Steckelberg JM, Patel R. Synovial fluid leukocyte count and differential for the diagnosis of prosthetic knee infection. Am J Med. 2004;117:556–562.

    PubMed  Article  Google Scholar 

  17. Trampuz A, Piper KE, Jacobson MJ, Hanssen AD, Unni KK, Osmon DR, Mandrekar JN, Cockerill FR, Steckelberg JM, Greenleaf JF, Patel R. Sonication of removed hip and knee prostheses for diagnosis of infection. N Engl J Med. 2007;357:654–663.

    PubMed  Article  CAS  Google Scholar 

Download references

Acknowledgments

We thank the following individuals for their involvement and invaluable input throughout the development of this document: Robert Barrack MD, Keith Berend MD, Sandra Berrios-Torres (from Centers for Disease Control and Prevention), Kevin Bozic MD, John Esterhai MD, Ryan Fagan (from Centers for Disease Control and Prevention), Thomas Fehring MD, Terry Gioe MD, Teresa Horan (from Centers for Disease Control and Prevention), Steven Kurtz PhD, Bas Masri MD, Arvind Nana MD, Douglas Osmon MD, John Segreti MD, and Mark Spangehl MD.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Javad Parvizi MD.

Additional information

Each author certifies that he or she, or a member of their immediate family, has no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article.

All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research editors and board members are on file with the publication and can be viewed on request.

About this article

Cite this article

Parvizi, J., Zmistowski, B., Berbari, E.F. et al. New Definition for Periprosthetic Joint Infection: From the Workgroup of the Musculoskeletal Infection Society. Clin Orthop Relat Res 469, 2992 (2011). https://doi.org/10.1007/s11999-011-2102-9

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11999-011-2102-9

Keywords

  • Acne
  • Periprosthetic Joint Infection
  • Periprosthetic Fracture
  • Periprosthetic Tissue
  • Inflammatory Arthropathy