Clinical Orthopaedics and Related Research®

, Volume 469, Issue 10, pp 2696–2705 | Cite as

Clinical Cartilage Restoration: Evolution and Overview

  • Jack FarrEmail author
  • Brian Cole
  • Aman Dhawan
  • James Kercher
  • Seth Sherman
Symposium: Clinically Relevant Strategies for Treating Cartilage and Meniscal



Clinical cartilage restoration is evolving, with established and emerging technologies. Randomized, prospective studies with adequate power comparing the myriad of surgical techniques used to treat chondral injuries are still lacking and it remains a challenge for the surgeon treating patients to make evidence-based decisions.


We reviewed the history of the major cartilage repair/restorative procedures, indications for currently available repair/restorative procedures, and postoperative management.


We performed searches using MEDLINE and cartilage-specific key words to identify all English-language literature. Articles were selected based on their contributions to our current understanding of the basic science and clinical treatment of articular cartilage lesions or historical importance. We then selected 77 articles, two of which are articles of historical importance.


Current cartilage restorative techniques include débridement, microfracture, osteochondral fragment repair, osteochondral allograft, osteochondral autograft, and autologous chondrocyte transplantation. Pending techniques include two-staged cell-based therapies integrated into a variety of scaffolds, single-stage cell-based therapy, and augmentation of marrow stimulation, each with suggested indications including lesion size, location, and activity demands of the patient. The literature demonstrates variable improvements in pain and function contingent upon multiple variables including indications and application.


For the patient with symptomatic chondral injury, numerous techniques are available to the surgeon to relieve pain and improve function. Until rigorous clinical trials (prospective, adequately powered, randomized control) are available, treatment decisions should be guided by expert extrapolation of the available literature based in historically sound principles.


Articular Cartilage Subchondral Bone Autologous Chondrocyte Implantation International Knee Documentation Committee Continuous Passive Motion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© The Association of Bone and Joint Surgeons® 2011

Authors and Affiliations

  • Jack Farr
    • 1
    • 2
    Email author
  • Brian Cole
    • 3
  • Aman Dhawan
    • 3
  • James Kercher
    • 3
  • Seth Sherman
    • 3
  1. 1.OrthoIndy Cartilage Restoration Center of IndianaGreenwoodUSA
  2. 2.Department of Orthopaedic SurgeryIndiana University School of MedicineIndianapolisUSA
  3. 3.Department of Orthopaedic SurgeryRush University Medical CenterChicagoUSA

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